Predictive Factors of Efficacy Maintenance after Testosterone Treatment Cessation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Min Gu | - |
dc.contributor.author | Yeo, Jeong Kyun | - |
dc.contributor.author | Park, Sun Gu | - |
dc.contributor.author | Na, Woong | - |
dc.contributor.author | Moon, Du Geon | - |
dc.date.accessioned | 2021-09-01T19:53:35Z | - |
dc.date.available | 2021-09-01T19:53:35Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/67795 | - |
dc.description.abstract | There is no conclusive evidence as to whether patients with testosterone deficiency (TD) who benefit from testosterone treatment (TRT) must continue the treatment for the rest of their lives. In some patients, the effect of TRT does not maintained after stopping TRT and, some patients show no significant TD symptoms, with normal testosterone levels after TRT cessation. Therefore, we investigated the predictive factors of response maintenance after TRT cessation. A total of 151 men with TD who responded to TRT were followed up for six months after TRT discontinuation. Ninety-two patients (Group I) failed to show response maintenance; 59 patients (Group II) had a maintained response. The groups did not differ in baseline characteristics or the type of TRT (oral, gel, short/long-acting injectables). However, TRT duration was significantly longer (10.7 vs. 5.2 months), and peak total testosterone (TT) level was significantly higher (713.7 vs. 546.1 ng/dL), in Group II than in Group I. More patients regularly exercised in Group II than in Group I (45.8% vs. 9.8%, p < 0.001). A multivariate logistic regression analysis revealed that exercise (B = 2.325, odds ratio = 10.231, p < 0.001) and TRT duration (B = 0.153, Exp(B) = 1.166, p < 0.001) were independent predictive factors of response maintenance. In men with TD who respond to TRT, longer treatment periods can improve the response durability after TRT cessation, regardless of the type of TRT. Additionally, regular exercise can increase the probability of maintaining the response after TRT cessation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | LATE-ONSET HYPOGONADISM | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | SEXUAL DYSFUNCTION | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | ANDROGEN | - |
dc.subject | THERAPY | - |
dc.subject | MEN | - |
dc.subject | RECOMMENDATIONS | - |
dc.subject | DEFICIENCY | - |
dc.subject | MORTALITY | - |
dc.title | Predictive Factors of Efficacy Maintenance after Testosterone Treatment Cessation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Moon, Du Geon | - |
dc.identifier.doi | 10.3390/jcm8020151 | - |
dc.identifier.wosid | 000460295400024 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.8, no.2 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | LATE-ONSET HYPOGONADISM | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | SEXUAL DYSFUNCTION | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | ANDROGEN | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordPlus | RECOMMENDATIONS | - |
dc.subject.keywordPlus | DEFICIENCY | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordAuthor | testosterone | - |
dc.subject.keywordAuthor | testosterone deficiency | - |
dc.subject.keywordAuthor | testosterone replacement therapy | - |
dc.subject.keywordAuthor | response maintenance | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.