Remote ischemic preconditioning ameliorates indirect acute lung injury by modulating phosphorylation of I kappa B alpha in mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Yun-Hee | - |
dc.contributor.author | Kim, Young-Sung | - |
dc.contributor.author | Kim, Byung-Hwa | - |
dc.contributor.author | Lee, Kuen-Su | - |
dc.contributor.author | Park, Hyung-Sun | - |
dc.contributor.author | Lim, Choon-Hak | - |
dc.date.accessioned | 2021-09-01T20:21:06Z | - |
dc.date.available | 2021-09-01T20:21:06Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0300-0605 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/67884 | - |
dc.description.abstract | Objective Acute lung injury is responsible for mortality in seriously ill patients. Previous studies have shown that systemic inflammation is attenuated by remote ischemic preconditioning (RIPC) via reducing nuclear factor-kappa B (NF-kappa B). Therefore, we investigated whether lipopolysaccharide (LPS)-induced indirect acute lung injury (ALI) can be protected by RIPC. Methods RIPC was accomplished by 10 minutes of occlusion using a tourniquet on the right hind limb of mice, followed by 10 minutes of reperfusion. This process was repeated three times. Intraperitoneal LPS (20 mg/kg) was administered to induce indirect ALI. Inflammatory cytokines in bronchoalveolar lavage fluid were analyzed using an enzyme-linked immunosorbent assay. Pulmonary tissue was excised for histological examination, and for examining NF-kappa B activity and phosphorylation of inhibitor of kappa B alpha (I kappa B alpha). Results NF-kappa B activation and LPS-induced histopathological changes in the lungs were significantly alleviated in the RIPC group. RIPC reduced phosphorylation of I kappa B alpha in lung tissue of ALI mice. Conclusions RIPC attenuates endotoxin-induced indirect ALI. This attenuation might occur through modification of NF-kappa B mediation of cytokines by modulating phosphorylation of I kappa B alpha. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | PROTECTS | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | INFLAMMATION | - |
dc.subject | ACTIVATION | - |
dc.subject | MECHANISMS | - |
dc.subject | PULMONARY | - |
dc.subject | OUTCOMES | - |
dc.subject | SHOCK | - |
dc.title | Remote ischemic preconditioning ameliorates indirect acute lung injury by modulating phosphorylation of I kappa B alpha in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young-Sung | - |
dc.contributor.affiliatedAuthor | Lim, Choon-Hak | - |
dc.identifier.doi | 10.1177/0300060518818300 | - |
dc.identifier.scopusid | 2-s2.0-85061372758 | - |
dc.identifier.wosid | 000458842200045 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v.47, no.2, pp.936 - 950 | - |
dc.relation.isPartOf | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | - |
dc.citation.title | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | - |
dc.citation.volume | 47 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 936 | - |
dc.citation.endPage | 950 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PULMONARY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | SHOCK | - |
dc.subject.keywordAuthor | Acute lung injury | - |
dc.subject.keywordAuthor | ischemic preconditioning | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | mice | - |
dc.subject.keywordAuthor | survival rate | - |
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