Study on High Density Scintillators and Multi-energy Windows for Improving I-131 Gamma Image Quality: Monte Carlo Simulation Approach
DC Field | Value | Language |
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dc.contributor.author | Kim, Minho | - |
dc.contributor.author | Bae, Jae Keon | - |
dc.contributor.author | Hong, Bong Hwan | - |
dc.contributor.author | Kim, Kyeong Min | - |
dc.contributor.author | Lee, Wonho | - |
dc.date.accessioned | 2021-09-01T21:01:55Z | - |
dc.date.available | 2021-09-01T21:01:55Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0374-4884 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/68208 | - |
dc.description.abstract | An energy window with a gamma peak centered at 364 keV (86%) is usually used for I-131 imaging. However, the image performance indexes such as image count, scatter fraction (SF), spatial resolution (SR) obtained using a conventional gamma camera, which uses a 3/8-in sodium iodide scintillator, are poor mainly due to its low detection efficiency. In this study, we investigated the feasibility of using a higher energy peak (637 and 723 keV) for the energy window to obtain a better imaging performance compared with the conventional I-131 imaging method. GATE (v7.0), which is based on Monte Carlo method, was used for performing simulations. A clinical gamma camera, SYMBIA-T2 (Siemens), was mounted on a NaI scintillator in the simulation. A GAGG scintillator was also realized for effective detection of high energy gamma, in addition to using high energy (HE) and ultrahigh energy (UHE) collimators. We obtained I-131 planar images through the conventionally used window method (364 keV +/- 10%). The high-energy gamma ray of I 131 (637 and 723 keV) have been additionally used for improving image performance. The scatter correction method was applied to images for suppressing scatter due to high-energy gamma rays. Various indexes are used for validating image performance such as SR, SF, and contrast-to-noise ratio. High-energy gamma rays could be used to increase the image counts, but the other image performances were degraded compared to the scatter-corrected 364 keV images (SF of 6.33 - 27.73%; SR of 0.93 - 6.02%). The UHE collimator was useful in obtaining a better spatial resolution and suppressing scatter components compared with the HE collimator. However, it did not exhibit a sufficient image performance to be considered as a replacement for the HE collimator. In order to use the high-energy gamma rays of I-131 (637 and 723 keV), it is necessary to design a new collimator to control penetration and improve resolution, instead of using a UHE collimator. Furthermore, scatter correction methods also need to be optimized. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN PHYSICAL SOC | - |
dc.subject | SCATTER CORRECTION | - |
dc.subject | RADIOIMMUNOTHERAPY | - |
dc.subject | DOSIMETRY | - |
dc.subject | SPECT/CT | - |
dc.subject | I-124 | - |
dc.subject | TOSITUMOMAB | - |
dc.subject | LYMPHOMA | - |
dc.subject | PET | - |
dc.title | Study on High Density Scintillators and Multi-energy Windows for Improving I-131 Gamma Image Quality: Monte Carlo Simulation Approach | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Wonho | - |
dc.identifier.doi | 10.3938/jkps.74.305 | - |
dc.identifier.scopusid | 2-s2.0-85061733524 | - |
dc.identifier.wosid | 000459205800018 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE KOREAN PHYSICAL SOCIETY, v.74, no.3, pp.305 - 311 | - |
dc.relation.isPartOf | JOURNAL OF THE KOREAN PHYSICAL SOCIETY | - |
dc.citation.title | JOURNAL OF THE KOREAN PHYSICAL SOCIETY | - |
dc.citation.volume | 74 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 305 | - |
dc.citation.endPage | 311 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002437171 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Physics, Multidisciplinary | - |
dc.subject.keywordPlus | SCATTER CORRECTION | - |
dc.subject.keywordPlus | RADIOIMMUNOTHERAPY | - |
dc.subject.keywordPlus | DOSIMETRY | - |
dc.subject.keywordPlus | SPECT/CT | - |
dc.subject.keywordPlus | I-124 | - |
dc.subject.keywordPlus | TOSITUMOMAB | - |
dc.subject.keywordPlus | LYMPHOMA | - |
dc.subject.keywordPlus | PET | - |
dc.subject.keywordAuthor | Iodine-131 | - |
dc.subject.keywordAuthor | Gamma-camera | - |
dc.subject.keywordAuthor | Monte Carlo simulation | - |
dc.subject.keywordAuthor | Scatter-Correction | - |
dc.subject.keywordAuthor | GAGG | - |
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