Futile reperfusion and predicted therapeutic benefits after successful endovascular treatment according to initial stroke severity
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang-Hwa | - |
dc.contributor.author | Kim, Beom Joon | - |
dc.contributor.author | Han, Moon-Ku | - |
dc.contributor.author | Park, Tai Hwan | - |
dc.contributor.author | Lee, Kyung Bok | - |
dc.contributor.author | Lee, Byung-Chul | - |
dc.contributor.author | Yu, Kyung-Ho | - |
dc.contributor.author | Oh, Mi Sun | - |
dc.contributor.author | Cha, Jae Kwan | - |
dc.contributor.author | Kim, Dae-Hyun | - |
dc.contributor.author | Nah, Hyun-Wook | - |
dc.contributor.author | Lee, Jun | - |
dc.contributor.author | Lee, Soo Joo | - |
dc.contributor.author | Kim, Jae Guk | - |
dc.contributor.author | Park, Jong-Moo | - |
dc.contributor.author | Kang, Kyusik | - |
dc.contributor.author | Cho, Yong-Jin | - |
dc.contributor.author | Hong, Keun-Sik | - |
dc.contributor.author | Park, Hong-Kyun | - |
dc.contributor.author | Choi, Jay Chol | - |
dc.contributor.author | Kim, Joon-Tae | - |
dc.contributor.author | Choi, Kangho | - |
dc.contributor.author | Kim, Dong-Eog | - |
dc.contributor.author | Ryu, Wi-Sun | - |
dc.contributor.author | Kim, Wook-Joo | - |
dc.contributor.author | Shin, Dong-Ick | - |
dc.contributor.author | Yeo, Minju | - |
dc.contributor.author | Sohn, Sung-Il | - |
dc.contributor.author | Hong, Jeong-Ho | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Lee, Ji Sung | - |
dc.contributor.author | Khatri, Pooja | - |
dc.contributor.author | Bae, Hee-Joon | - |
dc.date.accessioned | 2021-09-01T21:29:45Z | - |
dc.date.available | 2021-09-01T21:29:45Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-01-15 | - |
dc.identifier.issn | 1471-2377 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/68286 | - |
dc.description.abstract | BackgroundFutile reperfusion (poor functional status despite successful reperfusion) was observed in up to 67% of patients enrolled in recent endovascular treatment (EVT) clinical trials. We investigated the impact of baseline stroke severity on both futile reperfusion and therapeutic benefit of successful EVT.MethodsUsing a prospective multicenter stroke registry, we identified consecutive ischemic stroke patients with anterior circulation large artery occlusion, who were reperfused successfully by EVT (Thrombolysis in Cerebral Infarction grade 2b-3). The rate of futile reperfusion was assessed across the initial National Institutes of Health Stroke Scale (NIHSS) scores. The frequency of poor outcomes (modified Rankin scale [mRS] 3-6) according to NIHSS scores was compared between patients revascularized successfully by EVT and those who did not receive EVT, after standardizing for age.ResultsAmong 21,591 patients with ischemic stroke, 972 (4.5%) received EVT within 12h of onset, including 440 who met study eligibility criteria. Futile reperfusion was observed in 226 of the 440 study-eligible patients (51.4%) and was associated with stroke severity: 20.9% in NIHSS scores 5, 34.6% in 6-10, 58.9% in 11-20, and 63.8% in >20 (p<0.001). Nonetheless, the therapeutic benefit of EVT also increased with increasing stroke severity (p for interaction <0.001): 0.1% in NIHSS 5, 18.6% in 6-10, 28.7% in 11-20, and 34.3% in >20.ConclusionsEVT is more beneficial with increasing stroke severity, although futile reperfusion also increases with higher stroke severity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | ACUTE ISCHEMIC-STROKE | - |
dc.subject | HEALTH-CARE PROFESSIONALS | - |
dc.subject | INTRAVENOUS T-PA | - |
dc.subject | SUCCESSFUL REVASCULARIZATION | - |
dc.subject | INTRAARTERIAL TREATMENT | - |
dc.subject | EARLY MANAGEMENT | - |
dc.subject | THROMBECTOMY | - |
dc.subject | RECANALIZATION | - |
dc.subject | TIME | - |
dc.subject | METAANALYSIS | - |
dc.title | Futile reperfusion and predicted therapeutic benefits after successful endovascular treatment according to initial stroke severity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Juneyoung | - |
dc.identifier.doi | 10.1186/s12883-019-1237-2 | - |
dc.identifier.scopusid | 2-s2.0-85059989410 | - |
dc.identifier.wosid | 000455786600001 | - |
dc.identifier.bibliographicCitation | BMC NEUROLOGY, v.19 | - |
dc.relation.isPartOf | BMC NEUROLOGY | - |
dc.citation.title | BMC NEUROLOGY | - |
dc.citation.volume | 19 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | HEALTH-CARE PROFESSIONALS | - |
dc.subject.keywordPlus | INTRAVENOUS T-PA | - |
dc.subject.keywordPlus | SUCCESSFUL REVASCULARIZATION | - |
dc.subject.keywordPlus | INTRAARTERIAL TREATMENT | - |
dc.subject.keywordPlus | EARLY MANAGEMENT | - |
dc.subject.keywordPlus | THROMBECTOMY | - |
dc.subject.keywordPlus | RECANALIZATION | - |
dc.subject.keywordPlus | TIME | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordAuthor | Futile reperfusion | - |
dc.subject.keywordAuthor | Endovascular treatment | - |
dc.subject.keywordAuthor | Stroke severity | - |
dc.subject.keywordAuthor | Therapeutic benefit | - |
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