Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix
DC Field | Value | Language |
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dc.contributor.author | Parameswaran, Ramya | - |
dc.contributor.author | Koehler, Kelliann | - |
dc.contributor.author | Rotenberg, Menahem Y. | - |
dc.contributor.author | Burke, Michael J. | - |
dc.contributor.author | Kim, Jungkil | - |
dc.contributor.author | Jeong, Kwang-Yong | - |
dc.contributor.author | Hissa, Barbara | - |
dc.contributor.author | Paul, Michael D. | - |
dc.contributor.author | Moreno, Kiela | - |
dc.contributor.author | Sarma, Nivedina | - |
dc.contributor.author | Hayes, Thomas | - |
dc.contributor.author | Sudzilovsky, Edward | - |
dc.contributor.author | Park, Hong-Gyu | - |
dc.contributor.author | Tian, Bozhi | - |
dc.date.accessioned | 2021-09-01T21:34:51Z | - |
dc.date.available | 2021-09-01T21:34:51Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-01-08 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/68314 | - |
dc.description.abstract | Electronic pacemakers can treat electrical conduction disorders in hearts; however, they are invasive, bulky, and linked to increased incidence of infection at the tissue-device interface. Thus, researchers have looked to other more biocompatible methods for cardiac pacing or resynchronization, such as femtosecond infrared light pulsing, optogenetics, and polymer-based cardiac patches integrated with metal electrodes. Here we develop a biocompatible nongenetic approach for the optical modulation of cardiac cells and tissues. We demonstrate that a polymer-silicon nanowire composite mesh can be used to convert fast moving, low-radiance optical inputs into stimulatory signals in target cardiac cells. Our method allows for the stimulation of the cultured cardiomyocytes or ex vivo heart to beat at a higher target frequency. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | LASER | - |
dc.subject | GENERATION | - |
dc.title | Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hong-Gyu | - |
dc.identifier.doi | 10.1073/pnas.1816428115 | - |
dc.identifier.scopusid | 2-s2.0-85059643395 | - |
dc.identifier.wosid | 000455086900015 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.116, no.2, pp.413 - 421 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 116 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 413 | - |
dc.citation.endPage | 421 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | LASER | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordAuthor | cardiac | - |
dc.subject.keywordAuthor | silicon | - |
dc.subject.keywordAuthor | nanowire | - |
dc.subject.keywordAuthor | modulation | - |
dc.subject.keywordAuthor | optical | - |
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