pH-dependent regulation of SQSTM1/p62 during autophagy
DC Field | Value | Language |
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dc.contributor.author | Kwon, Do Hoon | - |
dc.contributor.author | Kim, Leehyeon | - |
dc.contributor.author | Song, Hyun Kyu | - |
dc.date.accessioned | 2021-09-01T21:40:46Z | - |
dc.date.available | 2021-09-01T21:40:46Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-01-02 | - |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/68347 | - |
dc.description.abstract | During macroautophagy/autophagy, SQSTM1/p62 plays dual roles as a key mediator of cargo selection and as an autophagic substrate. SQSTM1 links N-degrons and/or ubiquitinated cargoes to the autophagosome by forming homo- or hetero-oligomers, although its N-degron recognition and oligomerization mechanisms are not well characterized. We recently found that SQSTM1 is a novel type of N-recognin whose ZZ domain provides a negatively-charged binding pocket for Arg-charged N-degron (Nt-Arg), a prototype type-1 substrate. Although differences in binding affinity exist for each N-degron, SQSTM1 also interacts with type-2 N-degrons, such as Nt-Tyr and Nt-Trp. Intriguingly, interactions between SQSTM1's ZZ domain and various N-degrons are greatly influenced by pH-dependent SQSTM1 oligomerization via its PB1 domain. Because cellular pH conditions vary from neutral to acidic depending on the stage of autophagy, the pH-dependent regulation of SQSTM1's oligomerization must be tightly coupled with the autophagic process. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.title | pH-dependent regulation of SQSTM1/p62 during autophagy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Hyun Kyu | - |
dc.identifier.doi | 10.1080/15548627.2018.1532264 | - |
dc.identifier.scopusid | 2-s2.0-85054928415 | - |
dc.identifier.wosid | 000451574800016 | - |
dc.identifier.bibliographicCitation | AUTOPHAGY, v.15, no.1, pp.180 - 181 | - |
dc.relation.isPartOf | AUTOPHAGY | - |
dc.citation.title | AUTOPHAGY | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 180 | - |
dc.citation.endPage | 181 | - |
dc.type.rims | ART | - |
dc.type.docType | Editorial Material | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordAuthor | Aggrephagy | - |
dc.subject.keywordAuthor | autophagy adaptor | - |
dc.subject.keywordAuthor | HSPA5/BiP/GRP78 | - |
dc.subject.keywordAuthor | N-end rule | - |
dc.subject.keywordAuthor | pH-dependent oligomerization | - |
dc.subject.keywordAuthor | UBR box | - |
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