Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Tae Gun | - |
dc.contributor.author | Kim, Youn-Jung | - |
dc.contributor.author | Ryoo, Seung Mok | - |
dc.contributor.author | Hwang, Sung Yeon | - |
dc.contributor.author | Jo, Ik Joon | - |
dc.contributor.author | Chung, Sung Phil | - |
dc.contributor.author | Choi, Sung-Hyuk | - |
dc.contributor.author | Suh, Gil Joon | - |
dc.contributor.author | Kim, Won Young | - |
dc.date.accessioned | 2021-09-01T22:28:45Z | - |
dc.date.available | 2021-09-01T22:28:45Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/68811 | - |
dc.description.abstract | Background: Intravenous vitamin C and thiamine administration may be a potential adjuvant therapy for septic shock. We aimed to investigate the impact of early vitamin C and thiamine administration in septic shock patients. Methods: This retrospective before-and-after cohort study used data extracted from the Korean Shock Society's prospective septic shock registry. We compared 28-day and in-hospital mortality rates between patients treated with intravenous vitamin C (3 g/12 h or 1.5 g/6 h) and thiamine (200 mg/12 h) <6 h after shock recognition from July through December 2017 (n = 229) and control patients from October 2015 through June 2017 (n = 915) using propensity score matching. Results: The 28-day (18.3% vs. 17.5%; p = 0.76) and in-hospital (16.6% vs. 18.3%; p = 0.55) mortality rates did not differ between treatment and control groups, nor did 28-day (18.5% vs. 17.5%; p = 0.84) and in-hospital (16.7% vs. 18.4%; p = 0.54) mortality rates after matching. In the subgroup analysis, treatment was associated with lower in-hospital mortality rates in patients with albumin <3.0 mg/dL or a Sequential Organ Failure Assessment (SOFA) score >10. Conclusion: Early vitamin C and thiamine administration in patients with septic shock did not improve survival; however, administration could benefit conditions that are more severe, such as hypoalbuminemia or severe organ failure. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | CAMPAIGN INTERNATIONAL GUIDELINES | - |
dc.subject | ASCORBIC-ACID | - |
dc.subject | ORGAN FAILURE | - |
dc.subject | SEVERE SEPSIS | - |
dc.subject | HYDROCORTISONE | - |
dc.subject | RESUSCITATION | - |
dc.subject | MANAGEMENT | - |
dc.subject | TRIAL | - |
dc.subject | STEP | - |
dc.title | Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Sung-Hyuk | - |
dc.identifier.doi | 10.3390/jcm8010102 | - |
dc.identifier.wosid | 000457141100101 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.8, no.1 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CAMPAIGN INTERNATIONAL GUIDELINES | - |
dc.subject.keywordPlus | ASCORBIC-ACID | - |
dc.subject.keywordPlus | ORGAN FAILURE | - |
dc.subject.keywordPlus | SEVERE SEPSIS | - |
dc.subject.keywordPlus | HYDROCORTISONE | - |
dc.subject.keywordPlus | RESUSCITATION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | STEP | - |
dc.subject.keywordAuthor | sepsis | - |
dc.subject.keywordAuthor | septic shock | - |
dc.subject.keywordAuthor | thiamine | - |
dc.subject.keywordAuthor | vitamin C | - |
dc.subject.keywordAuthor | resuscitation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.