Preoperative assessment of malignant potential of gastrointestinal stromal tumor by dual-time-point 18F-fluorodeoxyglucose positron emission tomography imaging: Usefulness of standardized uptake value and retention index
DC Field | Value | Language |
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dc.contributor.author | Kwon, Yeongkeun | - |
dc.contributor.author | Park, Eunkyung | - |
dc.contributor.author | Pahk, Kisoo | - |
dc.contributor.author | Kim, Sungeun | - |
dc.contributor.author | Kim, Min Ju | - |
dc.contributor.author | Graf, Daniel | - |
dc.contributor.author | Park, Sungsoo | - |
dc.date.accessioned | 2021-09-01T22:29:19Z | - |
dc.date.available | 2021-09-01T22:29:19Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 0973-1482 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/68815 | - |
dc.description.abstract | Background: To evaluate the usefulness of preoperative imaging with F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) for noninvasive risk assessment of gastrointestinal stromal tumor (GIST). Materials and Methods: A retrospective review including 32 patients with pathologically proven GIST. Preoperative FDG-PET scan results including maximum standardized uptake values (SUVs) of the GISTs at 1 h postinjection (SUV1) were available for all tumors and SUVs at 2 h postinjection (SUV2) were available for 22 tumors. When both SUV1 and SUV2 were available, a retention index (RI, %) was calculated, and the correlation of these PET parameters with the histopathologic results was analyzed. Results: SUV1 was significantly higher in tumors in the high-risk group (6.0 +/- 2.7) compared to those in the low risk (3.0 +/- 1.6) or very low-risk (2.7 +/- 1.2) groups (P = 0.009 and 0.011, respectively). At a cutoff of 5.2, the SUV1 demonstrated sensitivity of 80% and a specificity of 89% for predicting high-risk GISTs. Tumor size was significantly correlated with SUV1 (r = 0.68, P < 0.001) and SUV2 (r = 0.66, P = 0.001), and SUV1, SUV2, and RI were significantly higher in tumors with mitotic index > 5/50 high-power field than in those with lower mitotic index. RI was significantly higher in tumors with C-kit mutation than in those with no C-kit mutation. Conclusion: SUV1 measured during preoperative FDG-PET imaging correlated well with malignant potential of GISTs, especially for high-risk versus Low-/very-low-risk tumors. RI values correlated well with mitotic counts and C-kit mutation, suggesting that this mutation may have some influence on tumor metabolism. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WOLTERS KLUWER MEDKNOW PUBLICATIONS | - |
dc.subject | SOFT-TISSUE SARCOMA | - |
dc.subject | FDG-PET | - |
dc.subject | F-18-FDG PET | - |
dc.subject | GIST | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | PREDICTION | - |
dc.subject | SUNITINIB | - |
dc.subject | DIAGNOSIS | - |
dc.subject | SURVIVAL | - |
dc.subject | LESIONS | - |
dc.title | Preoperative assessment of malignant potential of gastrointestinal stromal tumor by dual-time-point 18F-fluorodeoxyglucose positron emission tomography imaging: Usefulness of standardized uptake value and retention index | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwon, Yeongkeun | - |
dc.contributor.affiliatedAuthor | Kim, Sungeun | - |
dc.contributor.affiliatedAuthor | Kim, Min Ju | - |
dc.contributor.affiliatedAuthor | Park, Sungsoo | - |
dc.identifier.doi | 10.4103/jcrt.JCRT_1093_16 | - |
dc.identifier.scopusid | 2-s2.0-85063212699 | - |
dc.identifier.wosid | 000461542500025 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, v.15, no.1, pp.142 - 147 | - |
dc.relation.isPartOf | JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | - |
dc.citation.title | JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 142 | - |
dc.citation.endPage | 147 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | SOFT-TISSUE SARCOMA | - |
dc.subject.keywordPlus | FDG-PET | - |
dc.subject.keywordPlus | F-18-FDG PET | - |
dc.subject.keywordPlus | GIST | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | SUNITINIB | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordAuthor | Gastrointestinal stromal tumor | - |
dc.subject.keywordAuthor | positron emission tomography | - |
dc.subject.keywordAuthor | retention index | - |
dc.subject.keywordAuthor | standardized uptake value | - |
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