Assessment Of Changes In Regional Xenon-Ventilation, Perfusion, And Ventilation-Perfusion Mismatch Using Dual-EnergyComputed Tomography After Pharmacological Treatment In Patients With Chronic Obstructive Pulmonary Disease: Visual And Quantitative Analysis
DC Field | Value | Language |
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dc.contributor.author | Hwang, Hye Jeon | - |
dc.contributor.author | Lee, Sang Min | - |
dc.contributor.author | Seo, Joon Beom | - |
dc.contributor.author | Lee, Jae Seung | - |
dc.contributor.author | Kim, Namkug | - |
dc.contributor.author | Kim, Cherry | - |
dc.contributor.author | Oh, Sang Young | - |
dc.contributor.author | Lee, Sei Won | - |
dc.date.accessioned | 2021-09-01T22:47:30Z | - |
dc.date.available | 2021-09-01T22:47:30Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1176-9106 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/68947 | - |
dc.description.abstract | Purpose: To assess changes in regional ventilation (V), perfusion (Q), and V-Q mismatch in patients with chronic obstructive pulmonary disease (COPD) after pharmacologic treatment using combined xenon-enhanced V and iodine-enhanced Q dual-energy CT (DECT). Patients and methods: Combined V and Q DECT were performed at baseline and after three-month pharmacologic treatment in 52 COPD patients. Anatomically co-registered virtual non-contrast images, V, Q, and V/Q(ratio) maps were obtained. V/Q pattern was visually determined to be matched, mismatched, or reversed-mismatched and compared with the regional parenchymal disease patterns of each segment. DECT parameters for V, Q, and V-Q imbalance were quantified. Results: The parenchymal patterns on CT were not changed at follow-up. The segments with matched V/Q pattern were increased (80.2% to 83.6%) as the segments with reversed-mismatched V/Q pattern were decreased with improving ventilation (17.6% to 13.8%) after treatment. Changes of V/Q patterns were mostly observed in segments with bronchial wall thickening. Compared with patients without bronchial wall thickening, the quantified DECT parameters of V-Q imbalance were significantly improved in patients with bronchial wall thickening (p < 0.05). Changes in forced expiratory volume in one second after treatment were correlated with changes in the quantified DECT parameters (r = 0.327-0.342 or r = -0.406 and -0.303; p < 0.05). Conclusion: DECT analysis showed that the V-Q imbalance was improved after the pharmacological treatment in COPD patients, although the parenchymal disease patterns remained unchanged. This improvement of V-Q imbalance may occur mostly in the areas with bronchial wall thickening. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.subject | ENERGY COMPUTED-TOMOGRAPHY | - |
dc.subject | AIRWAY-OBSTRUCTION | - |
dc.subject | LUNG-FUNCTION | - |
dc.subject | CT | - |
dc.subject | COPD | - |
dc.subject | EMPHYSEMA | - |
dc.subject | DIAGNOSIS | - |
dc.subject | VOLUME | - |
dc.subject | SITE | - |
dc.title | Assessment Of Changes In Regional Xenon-Ventilation, Perfusion, And Ventilation-Perfusion Mismatch Using Dual-EnergyComputed Tomography After Pharmacological Treatment In Patients With Chronic Obstructive Pulmonary Disease: Visual And Quantitative Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Cherry | - |
dc.identifier.doi | 10.2147/COPD.S210555 | - |
dc.identifier.scopusid | 2-s2.0-85072847908 | - |
dc.identifier.wosid | 000489160800001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v.14, pp.2195 - 2203 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | - |
dc.citation.volume | 14 | - |
dc.citation.startPage | 2195 | - |
dc.citation.endPage | 2203 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | ENERGY COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | AIRWAY-OBSTRUCTION | - |
dc.subject.keywordPlus | LUNG-FUNCTION | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordPlus | COPD | - |
dc.subject.keywordPlus | EMPHYSEMA | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | SITE | - |
dc.subject.keywordAuthor | chronic obstructive pulmonary disease | - |
dc.subject.keywordAuthor | dual-energy computed tomography | - |
dc.subject.keywordAuthor | ventilation-perfusion mismatch | - |
dc.subject.keywordAuthor | pharmacotherapy | - |
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