Use of RBC deformability index as an early marker of diabetic nephropathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sang Bae | - |
dc.contributor.author | Kim, Yu-Sik | - |
dc.contributor.author | Kim, Jung Hye | - |
dc.contributor.author | Park, Kahui | - |
dc.contributor.author | Nam, Ji Sun | - |
dc.contributor.author | Kang, Shinae | - |
dc.contributor.author | Park, Jong Suk | - |
dc.contributor.author | Shin, Sehyun | - |
dc.contributor.author | Ahn, Chul Woo | - |
dc.date.accessioned | 2021-09-01T22:49:35Z | - |
dc.date.available | 2021-09-01T22:49:35Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1386-0291 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/68970 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVE: Hemorheologic alterations have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters and assessed their possible role as a diagnostic tool for diabetic nephropathy (DN). METHODS: 248 subjects with type 2 diabetes and 222 subjects with prediabetes were included in this study. Hemorheologic parameters, including erythrocyte sedimentation rate (ESR), elongation index at 3 Pa (EI) were measured using microfluidic hemorheometer. Various metabolic parameters were measured from fasting blood samples. The subjects were stratified into three groups according to classification of DN by urinary albumin to creatinine ratio (ACR) and four groups by estimated glomerular filtration rate (GFR), than analyzed. RESULTS: Significant differences were observed in metabolic and hemorheologic parameters according to progression of DN. Among them, (Fibrinogen x ESR)/ EI differed in all three groups of urinary ACR. In multiple regression analysis, (Fibrinogen x ESR)/ EI was an independent predictor of urine ACR after adjusted with confounding factors (beta = 0.010, p < 0.001). (Fibrinogen x ESR)/ EI also showed significant difference no or minimal CKD stage, moderate CKD and severe CKD classified by GFR. This parameter showed area under curve (AUC) of the receiver operating characteristic (ROC) curve of 0.762, and moderate sensitivity and specificity to predict prevalence of microalbuminuria. CONCLUSIONS: (Fibrinogen x ESR)/ EI is a sensitive parameter for screening diabetic nephropathy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.subject | BLOOD-CELL DEFORMABILITY | - |
dc.subject | CHRONIC KIDNEY-DISEASE | - |
dc.subject | SHEAR-STRESS | - |
dc.subject | MICROALBUMINURIA | - |
dc.subject | ASSOCIATION | - |
dc.subject | AGGREGATION | - |
dc.subject | PROTEINURIA | - |
dc.subject | MELLITUS | - |
dc.subject | ALBUMIN | - |
dc.subject | ADULTS | - |
dc.title | Use of RBC deformability index as an early marker of diabetic nephropathy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Sehyun | - |
dc.identifier.doi | 10.3233/CH-180434 | - |
dc.identifier.scopusid | 2-s2.0-85069650631 | - |
dc.identifier.wosid | 000476864200006 | - |
dc.identifier.bibliographicCitation | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, v.72, no.1, pp.75 - 84 | - |
dc.relation.isPartOf | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | - |
dc.citation.title | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | - |
dc.citation.volume | 72 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 75 | - |
dc.citation.endPage | 84 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | BLOOD-CELL DEFORMABILITY | - |
dc.subject.keywordPlus | CHRONIC KIDNEY-DISEASE | - |
dc.subject.keywordPlus | SHEAR-STRESS | - |
dc.subject.keywordPlus | MICROALBUMINURIA | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | PROTEINURIA | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | ALBUMIN | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordAuthor | Diabetic nephropathy | - |
dc.subject.keywordAuthor | RBC deformability | - |
dc.subject.keywordAuthor | hemorheology | - |
dc.subject.keywordAuthor | elongation index | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.