Recapitulation of molecular regulators of nuclear motion during cell migration
- Authors
- Sneider, Alexandra; Hah, Jungwon; Wirtz, Denis; Kim, Dong-Hwee
- Issue Date
- 2019
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- Nuclear mechanics; Cell migration; LINC complex; Cytoskeleton
- Citation
- CELL ADHESION & MIGRATION, v.13, no.1, pp.50 - 62
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELL ADHESION & MIGRATION
- Volume
- 13
- Number
- 1
- Start Page
- 50
- End Page
- 62
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/69022
- DOI
- 10.1080/19336918.2018.1506654
- ISSN
- 1933-6918
- Abstract
- Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.