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PHMG-Phosphate의 직업적 유해성평가를 통한 노출기준 제안 연구Recommendation of Occupational Exposure Limit through occupational hazard assessment of PHMG-Phosphate

Other Titles
Recommendation of Occupational Exposure Limit through occupational hazard assessment of PHMG-Phosphate
Authors
이혜림변상훈이권섭
Issue Date
2019
Publisher
한국산업보건학회
Keywords
biocide; no observed adverse effect level(NOAEL); occupational exposure limits(OELs); PHMG; RfCworker
Citation
한국산업보건학회지, v.29, no.1, pp.13 - 20
Indexed
KCI
Journal Title
한국산업보건학회지
Volume
29
Number
1
Start Page
13
End Page
20
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/70612
DOI
10.15269/JKSOEH.2019.29.1.13
ISSN
2384-132x
Abstract
Objective: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker(RfCworker) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for PHMG- Phosphate(CAS No. 89697-78-9), It is a humidifier disinfectant that generated many lung injuries. Methods: We have investigated the recommendation or guidelines of foreign OEL for PHMG-Phosphate and the actual state of legal management in Korea. To examine the procedures and methods for recommendation OEL. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity RfCworker value was calculated for PHMG-Phosphate. An OEL and the necessity of legal management were recommended as well. Results and Conclusions: The OEL for PHMG-Phosphate is recommended to be 0.01 mg/㎥. The recommended OEL is close to 10 times the RfCworker value of 0.000833 mg/㎥ calculated from the chemical dose-response hazard assessment, which is a 2017 study. The CMIT/MIT(3:1) mixture, which was a social issue as a humidifier disinfectant substance, was also exposed to the same ratio in March 2018, establish the OEL. It is recommended to establish OEL for PHMG-Phosphate to prevent worker health hazards and for chemical safety management.
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