Treat-to-Target Strategy for Asian Patients with Early Rheumatoid Arthritis: Result of a Multicenter Trial in Korea
DC Field | Value | Language |
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dc.contributor.author | Song, Jason Jungsik | - |
dc.contributor.author | Song, Yeong Wook | - |
dc.contributor.author | Bae, Sang Cheol | - |
dc.contributor.author | Cha, Hoon-Suk | - |
dc.contributor.author | Choe, Jung-Yoon | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Kim, Hyun Ah | - |
dc.contributor.author | Kim, Jinseok | - |
dc.contributor.author | Kim, Sung-Soo | - |
dc.contributor.author | Lee, Choong-Ki | - |
dc.contributor.author | Lee, Jisoo | - |
dc.contributor.author | Lee, Sang-Heon | - |
dc.contributor.author | Lee, Shin-Seok | - |
dc.contributor.author | Lee, Soo-Kon | - |
dc.contributor.author | Lee, Sung Won | - |
dc.contributor.author | Park, Sung-Hwan | - |
dc.contributor.author | Park, Won | - |
dc.contributor.author | Shim, Seung Cheol | - |
dc.contributor.author | Suh, Chang-Hee | - |
dc.contributor.author | Yoo, Bin | - |
dc.contributor.author | Yoo, Dae-Hyun | - |
dc.contributor.author | Yoo, Wan-Hee | - |
dc.date.accessioned | 2021-09-02T01:36:38Z | - |
dc.date.available | 2021-09-02T01:36:38Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-12-24 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/70869 | - |
dc.description.abstract | Background: To evaluate the therapeutic benefits of the treat-to-target (T2T) strategy for Asian patients with early rheumatoid arthritis (RA) in Korea. Methods: In a 1-year, multicenter, open-label strategy trial, 346 patients with early RA were recruited from 20 institutions across Korea and stratified into 2 groups, depending on whether they were recruited by rheumatologists who have adopted the T2T strategy (T2T group) or by rheumatologists who provided usual care (non-T2T group). Data regarding demographics, rheumatoid factor titer, anti-cyclic citrullinated peptide antibody titer, disease activity score of 28 joints (DAS28), and Korean Health Assessment Questionnaire (KHAQ) score were obtained at baseline and after 1 year of treatment. In the T2T group, the prescription for disease-modifying antirheumatic drugs was tailored to the predefined treatment target in each patient, namely remission (DAS28 < 2.6) or low disease activity (LDA) (2.6 <= DAS28 < 3.2). Results: Data were available for 163 T2T patients and 162 non-T2T patients. At the end of the study period, clinical outcomes were better in the T2T group than in the non T2T group (LDA or remission, 59.5% vs. 35.8%; P < 0.001; remission, 43.6% vs. 19.8%; P < 0.001). Compared with non-T2T, T2T was also associated with higher rate of good European League Against Rheumatism response (63.0% vs. 39.8%; P < 0.001), improved KHAQ scores (-0.38 vs. -0.13; P= 0.008), and higher frequency of follow-up visits (5.0 vs. 2.0 visits/year; P < 0.001). Conclusion: In Asian patients with early RA, T2T improves disease activity and physical function. Setting a pre-defined treatment target in terms of DAS28 is recommended. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | TIGHT CONTROL | - |
dc.subject | RECOMMENDATIONS | - |
dc.subject | REMISSION | - |
dc.subject | CRITERIA | - |
dc.title | Treat-to-Target Strategy for Asian Patients with Early Rheumatoid Arthritis: Result of a Multicenter Trial in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.identifier.doi | 10.3346/jkms.2018.33.e346 | - |
dc.identifier.scopusid | 2-s2.0-85058910437 | - |
dc.identifier.wosid | 000454243800007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.33, no.52 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 33 | - |
dc.citation.number | 52 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002420251 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | TIGHT CONTROL | - |
dc.subject.keywordPlus | RECOMMENDATIONS | - |
dc.subject.keywordPlus | REMISSION | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordAuthor | Rheumatoid Arthritis | - |
dc.subject.keywordAuthor | Treatment Outcome | - |
dc.subject.keywordAuthor | Treat-to-target | - |
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