Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Early venous thromboembolism at the beginning of palliative chemotherapy is a poor prognostic factor in patients with metastatic pancreatic cancer: a retrospective study

Authors
Kim, Jung SunKang, Eun JooKim, Dae SikChoi, Yoon JiLee, Suk YoungKim, Hong JunSeo, Hee YeonKim, Jun Suk
Issue Date
17-12월-2018
Publisher
BMC
Keywords
Pancreatic cancer; Venous thromboembolism; Prognosis; Predictive value; Chemotherapy; Khorana score; Hyponatremia
Citation
BMC CANCER, v.18
Indexed
SCIE
SCOPUS
Journal Title
BMC CANCER
Volume
18
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/70887
DOI
10.1186/s12885-018-5154-3
ISSN
1471-2407
Abstract
BackgroundThis study investigated the prognostic effects of venous thromboembolism (VTE)-related factors in patients with metastatic pancreatic cancer receiving palliative chemotherapy. Predictive factors for VTE were also investigated.MethodsA total of 216 patients diagnosed with metastatic pancreatic cancer who received gemcitabine-based palliative chemotherapy at our institution were retrospectively evaluated.ResultsVTE occurred in 51 (23.6%) patients during treatment and did not affect survival. However, patients who were diagnosed with VTE at the beginning of chemotherapy showed poor prognosis compared with patients diagnosed with VTE during chemotherapy: all patients (hazard ratio [HR] 1.897, p=0.008); patients diagnosed with VTE (HR=3.768, p=0.001). Low serum sodium (Na) (<135mmol/L) and high Khorana score (3) were strong predictive factors of early VTE (odds ratio [OR] 5.109; 95% confidence interval [95% CI]=1.010-25.845; p=0.049 for Khorana score, OR 10.304; 95% CI=1.036-102.466; p=0.047) for hyponatremia).ConclusionsOur study demonstrated that occurrence and detection of VTE in the early period of chemotherapy was the most significant VTE-related prognostic factor in patients with metastatic pancreatic cancer receiving chemotherapy. Prediction using the Khorana score and serum Na levels would be helpful in early diagnosis of VTE.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE