A risk stratification model for nodal peripheral T-cell lymphomas based on the NCCN-IPI and posttreatment Deauville score
DC Field | Value | Language |
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dc.contributor.author | Yhim, Ho-Young | - |
dc.contributor.author | Park, Yong | - |
dc.contributor.author | Han, Yeon-Hee | - |
dc.contributor.author | Kim, Sungeun | - |
dc.contributor.author | Kang, Sae-Ryung | - |
dc.contributor.author | Moon, Joon-Ho | - |
dc.contributor.author | Jeong, Ju Hye | - |
dc.contributor.author | Shin, Ho-Jin | - |
dc.contributor.author | Kim, Keunyoung | - |
dc.contributor.author | Choi, Yoon Seok | - |
dc.contributor.author | Kim, Kunho | - |
dc.contributor.author | Kim, Min Kyoung | - |
dc.contributor.author | Kong, Eunjung | - |
dc.contributor.author | Kim, Dae Sik | - |
dc.contributor.author | Eo, Jae Seon | - |
dc.contributor.author | Lee, Ji Hyun | - |
dc.contributor.author | Kang, Do-Young | - |
dc.contributor.author | Lee, Won Sik | - |
dc.contributor.author | Lee, Seok Mo | - |
dc.contributor.author | Do, Young Rok | - |
dc.contributor.author | Ham, Jun Soo | - |
dc.contributor.author | Kim, Seok Jin | - |
dc.contributor.author | Kim, Won Seog | - |
dc.contributor.author | Choi, Joon Young | - |
dc.contributor.author | Yang, Deok-Hwan | - |
dc.contributor.author | Kwak, Jae-Yong | - |
dc.date.accessioned | 2021-09-02T02:26:42Z | - |
dc.date.available | 2021-09-02T02:26:42Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 1619-7070 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/71334 | - |
dc.description.abstract | PurposeThe aim of this study was to establish a risk-stratification model integrating posttreatment metabolic response using the Deauville score and the pretreatment National Comprehensive Cancer Network-International Prognostic Index (NCCN-IPI) in nodal PTCLs.MethodsWe retrospectively analysed 326 patients with newly diagnosed nodal PTCLs between January 2005 and June 2016 and both baseline and posttreatment PET/CT data. The final model was validated using an independent prospective cohort of 79 patients.ResultsPosttreatment Deauville score (1/2, 3, and 4/5) and the NCCN-IPI (low, low-intermediate, high-intermediate, and high) were independently associated with progression-free survival: for the Deauville score, the hazard ratios (HRs) were 1.00 vs. 2.16 (95% CI 1.47-3.18) vs. 7.86 (5.66-10.92), P<0.001; and for the NCCN-IPI, the HRs were 1.00 vs. 2.31 (95% CI 1.20-4.41) vs. 4.42 (2.36-8.26) vs. 7.09 (3.57-14.06), P<0.001. Based on these results, we developed a simplified three-group risk model comprising a low-risk group (low or low-intermediate NCCN-IPI with a posttreatment Deauville score of 1 or 2, or low NCCN-IPI with a Deauville score of 3), a high-risk group (high or high-intermediate NCCN-IPI with a Deauville score of 1/2 or 3, or low-intermediate NCCN-IPI with a Deauville score of 3), and a treatment failure group (Deauville score 4 or 5). This model was significantly associated with progression-free survival (5-year, 70.3%, 31.4%, and 4.7%; P<0.001) and overall survival (5-year, 82.1%, 45.5%, and 14.7%; P<0.001). Similar associations were also observed in the independent validation cohort.ConclusionThe risk-stratification model integrating posttreatment Deauville score and pretreatment NCCN-IPI is a powerful tool for predicting treatment failure in patients with nodal PTCLs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | HODGKIN-LYMPHOMA | - |
dc.subject | INTERPRETATION CRITERIA | - |
dc.subject | MALIGNANT-LYMPHOMAS | - |
dc.subject | RESPONSE EVALUATION | - |
dc.subject | INTERIM | - |
dc.title | A risk stratification model for nodal peripheral T-cell lymphomas based on the NCCN-IPI and posttreatment Deauville score | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yong | - |
dc.contributor.affiliatedAuthor | Kim, Sungeun | - |
dc.contributor.affiliatedAuthor | Kim, Dae Sik | - |
dc.contributor.affiliatedAuthor | Eo, Jae Seon | - |
dc.identifier.doi | 10.1007/s00259-018-4093-1 | - |
dc.identifier.scopusid | 2-s2.0-85050828172 | - |
dc.identifier.wosid | 000450713500006 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, v.45, no.13, pp.2274 - 2284 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.citation.title | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.citation.volume | 45 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 2274 | - |
dc.citation.endPage | 2284 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | HODGKIN-LYMPHOMA | - |
dc.subject.keywordPlus | INTERPRETATION CRITERIA | - |
dc.subject.keywordPlus | MALIGNANT-LYMPHOMAS | - |
dc.subject.keywordPlus | RESPONSE EVALUATION | - |
dc.subject.keywordPlus | INTERIM | - |
dc.subject.keywordAuthor | Peripheral T-cell lymphoma | - |
dc.subject.keywordAuthor | PET | - |
dc.subject.keywordAuthor | CT | - |
dc.subject.keywordAuthor | International prognostic index | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Treatment | - |
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