Ceria Nanoparticles Synthesized With Aminocaproic Acid for the Treatment of Subarachnoid Hemorrhage
DC Field | Value | Language |
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dc.contributor.author | Jeong, Han-Gil | - |
dc.contributor.author | Cha, Bong Geun | - |
dc.contributor.author | Kang, Dong-Wan | - |
dc.contributor.author | Kim, Do Yeon | - |
dc.contributor.author | Ki, Seul Ki | - |
dc.contributor.author | Kim, Song I. | - |
dc.contributor.author | Han, Ju Hee | - |
dc.contributor.author | Yang, Wookjin | - |
dc.contributor.author | Kim, Chi Kyung | - |
dc.contributor.author | Kim, Jaeyun | - |
dc.contributor.author | Lee, Seung-Hoon | - |
dc.date.accessioned | 2021-09-02T02:43:04Z | - |
dc.date.available | 2021-09-02T02:43:04Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 0039-2499 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/71481 | - |
dc.description.abstract | Background and Purpose-Despite early aneurysm repair and aggressive management for complications, subarachnoid hemorrhage (SAH) results in at least 25% mortality rate and 50% persistent neurological deficit. We investigated whether ceria nanoparticles which have potent antioxidative activities can protect against subarachnoid hemorrhage via attenuating fatal brain injuries. Methods-Uniform, 3 nm, water-dispersed ceria nanoparticles were prepared from short sol-gel reaction of cerium (III) ions with aminocaproic acid in aqueous phase. SAH was induced by endovascular perforation of middle cerebral artery of rats. A single dose of ceria nanoparticles (0.5 mg Ce/kg) or saline control was randomly administered intravenously at an hour post-SAH. Neuronal death, macrophage infiltration, SAH grade, and brain edema were evaluated at 72 hours. Mortality and neurological function were assessed for 14 days. Results-The obtained ceria nanoparticles with high Ce3+ to Ce4+ ratio demonstrated potent antioxidative, cytoprotective, and anti-inflammatory activities in vitro. In rodent SAH models, the severity of hemorrhage was comparable between the ceria nanoparticles- and saline-treated groups. However, ceria nanoparticles significantly reduced neuronal death, macrophage infiltration, and brain edema after SAH. Ceria nanoparticles successfully improved survival rates (88.2% in the ceria nanoparticles group versus 21.1% in the control group; P<0.001) and neurological outcomes (modified Garcia score: 12.1 +/- 0.5 in the ceria nanoparticles group versus 4.4 +/- 0.5 in the control group; P<0.001) of the animals with SAH. Conclusions-Ceria nanoparticles, totally synthesized in aqueous phase using aminocaproic acid, demonstrated promising results against SAH via potent antioxidative, neuroprotective and anti-inflammatory activities. Given the obvious limitations of current therapies for SAH, ceria nanoparticles can be a potential therapeutic agent which might result in a paradigm shift in SAH treatment. Visual Overview-An online visual overview is available for this article. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | EARLY BRAIN-INJURY | - |
dc.subject | SUPEROXIDE-DISMUTASE | - |
dc.subject | BLOOD-FLOW | - |
dc.subject | DEATH | - |
dc.subject | INHIBITION | - |
dc.subject | MECHANISMS | - |
dc.subject | NECROSIS | - |
dc.subject | STRESS | - |
dc.subject | MODEL | - |
dc.title | Ceria Nanoparticles Synthesized With Aminocaproic Acid for the Treatment of Subarachnoid Hemorrhage | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chi Kyung | - |
dc.identifier.doi | 10.1161/STROKEAHA.118.022631 | - |
dc.identifier.scopusid | 2-s2.0-85058910010 | - |
dc.identifier.wosid | 000456427700045 | - |
dc.identifier.bibliographicCitation | STROKE, v.49, no.12, pp.3030 - 3038 | - |
dc.relation.isPartOf | STROKE | - |
dc.citation.title | STROKE | - |
dc.citation.volume | 49 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3030 | - |
dc.citation.endPage | 3038 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | EARLY BRAIN-INJURY | - |
dc.subject.keywordPlus | SUPEROXIDE-DISMUTASE | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | NECROSIS | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | nanomedicine | - |
dc.subject.keywordAuthor | neuroprotective agents | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | stroke | - |
dc.subject.keywordAuthor | subarachnoid hemorrhage | - |
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