Progress toward a group B streptococcal vaccine
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Joon Young | - |
dc.contributor.author | Lim, Jae Hyang | - |
dc.contributor.author | Lim, Sangyong | - |
dc.contributor.author | Yong, Zhi | - |
dc.contributor.author | Seo, Ho Seong | - |
dc.date.accessioned | 2021-09-02T04:04:02Z | - |
dc.date.available | 2021-09-02T04:04:02Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-11-02 | - |
dc.identifier.issn | 2164-5515 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/71889 | - |
dc.description.abstract | Streptococcus agalactiae (group B Streptococcus, GBS) is a leading cause of severe invasive disease in neonate, elderly, and immunocompromised patients worldwide. Despite recent advances in the diagnosis and intrapartum antibiotic prophylaxis (IAP) of GBS infections, it remains one of the most common causes of neonatal morbidity and mortality, causing serious infections. Furthermore, recent studies reported an increasing number of GBS infections in pregnant women and elderly. Although IAP is effective, it has several limitations, including increasing antimicrobial resistance and late GBS infection after negative antenatal screening. Maternal immunization is the most promising and effective countermeasure against GBS infection in neonates. However, no vaccine is available to date, but two types of vaccines, protein subunit and capsular polysaccharide conjugate vaccines, were investigated in clinical trials. Here, we provide an overview of the GBS vaccine development status and recent advances in the development of immunoassays to evaluate the GBS vaccine clinical efficacy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.subject | ALPHA-C-PROTEIN | - |
dc.subject | POLYSACCHARIDE CONJUGATE VACCINES | - |
dc.subject | LINKED-IMMUNOSORBENT-ASSAY | - |
dc.subject | CROSS-REACTIVE ANTIBODIES | - |
dc.subject | RICH REPEAT PROTEINS | - |
dc.subject | CAPSULAR POLYSACCHARIDE | - |
dc.subject | C5A PEPTIDASE | - |
dc.subject | SURFACE-PROTEINS | - |
dc.subject | MATERNAL ANTIBODY | - |
dc.subject | PREGNANT-WOMEN | - |
dc.title | Progress toward a group B streptococcal vaccine | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Joon Young | - |
dc.identifier.doi | 10.1080/21645515.2018.1493326 | - |
dc.identifier.scopusid | 2-s2.0-85058711073 | - |
dc.identifier.wosid | 000453933500020 | - |
dc.identifier.bibliographicCitation | HUMAN VACCINES & IMMUNOTHERAPEUTICS, v.14, no.11, pp.2669 - 2681 | - |
dc.relation.isPartOf | HUMAN VACCINES & IMMUNOTHERAPEUTICS | - |
dc.citation.title | HUMAN VACCINES & IMMUNOTHERAPEUTICS | - |
dc.citation.volume | 14 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2669 | - |
dc.citation.endPage | 2681 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | ALPHA-C-PROTEIN | - |
dc.subject.keywordPlus | POLYSACCHARIDE CONJUGATE VACCINES | - |
dc.subject.keywordPlus | LINKED-IMMUNOSORBENT-ASSAY | - |
dc.subject.keywordPlus | CROSS-REACTIVE ANTIBODIES | - |
dc.subject.keywordPlus | RICH REPEAT PROTEINS | - |
dc.subject.keywordPlus | CAPSULAR POLYSACCHARIDE | - |
dc.subject.keywordPlus | C5A PEPTIDASE | - |
dc.subject.keywordPlus | SURFACE-PROTEINS | - |
dc.subject.keywordPlus | MATERNAL ANTIBODY | - |
dc.subject.keywordPlus | PREGNANT-WOMEN | - |
dc.subject.keywordAuthor | group B Streptococcus | - |
dc.subject.keywordAuthor | maternal immunization | - |
dc.subject.keywordAuthor | Streptococcus agalactiae | - |
dc.subject.keywordAuthor | vaccine | - |
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