Vascularization of PLGA-based bio-artificial beds by hypoxia-preconditioned mesenchymal stem cells for subcutaneous xenogeneic islet transplantation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Soo Hyun | - |
dc.date.accessioned | 2021-09-02T04:06:58Z | - |
dc.date.available | 2021-09-02T04:06:58Z | - |
dc.date.created | 2021-06-21 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 0908-665X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/71914 | - |
dc.description.abstract | Background Subcutaneous tissue is an attractive extra-hepatic heterotopic site for islet transplantation; however, poor oxygen tension and blood supply during early engraftment of implanted islets have limited the use of this site in clinical applications. Methods This study investigated the vascularization potential of hypoxia-preconditioned mesenchymal stem cells (3% O-2; hypo-MSCs) in PLGA-based bio-artificial beds for subsequent subcutaneous islet transplantation. Sheet-typed polymeric PLGA scaffolds coated with hypo-MSCs or normo-MSCs (MSCs cultured under normoxia conditions, 21% O-2) were implanted subcutaneously in mice. Results Compared to normo-MSCs, hypo-MSCs significantly enhanced vasculogenesis, both on the interior and exterior surfaces of the implanted PLGA devices, which peaked 4 weeks after implantation. Further, infusion of porcine islets inside the prevascularized PLGA bed restored normal glycemic control in 6 of 6 STZ-induced diabetic mice. The mass of the marginal islet was approximately 2000 IEQs, which is comparable to that required for the renal subcapsular space, a highly vascularized site. Conclusions Therefore, PLGA-based bio-artificial devices prevascularized with hypo-MSCs could be a useful modality for successful subcutaneous islet transplantation, wh | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Vascularization of PLGA-based bio-artificial beds by hypoxia-preconditioned mesenchymal stem cells for subcutaneous xenogeneic islet transplantation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Soo Hyun | - |
dc.identifier.doi | 10.1111/xen.12441 | - |
dc.identifier.bibliographicCitation | XENOTRANSPLANTATION, v.26, no.1 | - |
dc.relation.isPartOf | XENOTRANSPLANTATION | - |
dc.citation.title | XENOTRANSPLANTATION | - |
dc.citation.volume | 26 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.