Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion
DC Field | Value | Language |
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dc.contributor.author | Hamoud, Noumeira | - |
dc.contributor.author | Tran, Viviane | - |
dc.contributor.author | Aimi, Takahiro | - |
dc.contributor.author | Kakegawa, Wataru | - |
dc.contributor.author | Lahaie, Sylvie | - |
dc.contributor.author | Thibault, Marie-Pier | - |
dc.contributor.author | Pelletier, Ariane | - |
dc.contributor.author | Wong, G. William | - |
dc.contributor.author | Kim, In-San | - |
dc.contributor.author | Kania, Artur | - |
dc.contributor.author | Yuzaki, Michisuke | - |
dc.contributor.author | Bouvier, Michel | - |
dc.contributor.author | Cote, Jean-Francois | - |
dc.date.accessioned | 2021-09-02T05:01:48Z | - |
dc.date.available | 2021-09-02T05:01:48Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-10-26 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72437 | - |
dc.description.abstract | Myoblast fusion is tightly regulated during development and regeneration of muscle fibers. BAI3 is a receptor that orchestrates myoblast fusion via Elmo/Dock1 signaling, but the mechanisms regulating its activity remain elusive. Here we report that mice lacking BAI3 display small muscle fibers and inefficient muscle regeneration after cardiotoxin-induced injury. We describe two proteins that repress or activate BAI3 in muscle progenitors. We find that the secreted C1q-like1-4 proteins repress fusion by specifically interacting with BAI3. Using a proteomic approach, we identify Stabilin-2 as a protein that interacts with BAI3 and stimulates its fusion promoting activity. We demonstrate that Stabilin-2 activates the GPCR activity of BAI3. The resulting activated heterotrimeric G-proteins contribute to the initial recruitment of Elmo proteins to the membrane, which are then stabilized on BAI3 through a direct interaction. Collectively, our results demonstrate that the activity of BAI3 is spatiotemporally regulated by C1qL4 and Stabilin-2 during myoblast fusion. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CELL CORPSE CLEARANCE | - |
dc.subject | COUPLED RECEPTOR BAI3 | - |
dc.subject | MYOGENIC DIFFERENTIATION | - |
dc.subject | MUSCLE DEVELOPMENT | - |
dc.subject | G-PROTEIN | - |
dc.subject | IN-VIVO | - |
dc.subject | ANGIOGENESIS INHIBITOR-1 | - |
dc.subject | C1Q-LIKE PROTEINS | - |
dc.subject | APOPTOTIC CELLS | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.title | Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, In-San | - |
dc.identifier.doi | 10.1038/s41467-018-06897-5 | - |
dc.identifier.scopusid | 2-s2.0-85055614656 | - |
dc.identifier.wosid | 000448414100020 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.9 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CELL CORPSE CLEARANCE | - |
dc.subject.keywordPlus | COUPLED RECEPTOR BAI3 | - |
dc.subject.keywordPlus | MYOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | MUSCLE DEVELOPMENT | - |
dc.subject.keywordPlus | G-PROTEIN | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ANGIOGENESIS INHIBITOR-1 | - |
dc.subject.keywordPlus | C1Q-LIKE PROTEINS | - |
dc.subject.keywordPlus | APOPTOTIC CELLS | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
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