Internal interaction changes within the mutation of SLC26A4 STAS domain
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jae In | - |
dc.contributor.author | Chang, Hyunjoon | - |
dc.contributor.author | Lee, Myeongsang | - |
dc.contributor.author | Na, Sungsoo | - |
dc.date.accessioned | 2021-09-02T05:07:54Z | - |
dc.date.available | 2021-09-02T05:07:54Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-10-16 | - |
dc.identifier.issn | 0009-2614 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72470 | - |
dc.description.abstract | Pendrin (SLC26A4) is a protein associated with the auditory system. Pendred syndrome (PDS) and DFNB4 are typical auditory disorders caused by mutations in the SLC26A4 STAS domain. We generated an SLC26A4 STAS domain model and six mutated STAS domain models related to PDS, DFNB4, and PDS/DFNB4 by homology modeling. Molecular dynamics simulation was performed to find the equilibration conformation and fluctuation information. Using fluctuation information, we calculated betweenness centrality and edge betweenness to reveal communication between secondary structures of STAS domain. The edge betweenness results showed that mutated models generate communication signals that are less clear than WT models. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | GENOTYPE-PHENOTYPE CORRELATION | - |
dc.subject | MOLECULAR-DYNAMICS | - |
dc.subject | COMPLEX NETWORKS | - |
dc.subject | PENDRED-SYNDROME | - |
dc.subject | MOTOR PROTEIN | - |
dc.subject | HEARING-LOSS | - |
dc.subject | PDS GENE | - |
dc.subject | PRESTIN | - |
dc.subject | ENLARGEMENT | - |
dc.subject | CENTRALITY | - |
dc.title | Internal interaction changes within the mutation of SLC26A4 STAS domain | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Sungsoo | - |
dc.identifier.doi | 10.1016/j.cplett.2018.09.002 | - |
dc.identifier.scopusid | 2-s2.0-85053122115 | - |
dc.identifier.wosid | 000445778000037 | - |
dc.identifier.bibliographicCitation | CHEMICAL PHYSICS LETTERS, v.710, pp.226 - 233 | - |
dc.relation.isPartOf | CHEMICAL PHYSICS LETTERS | - |
dc.citation.title | CHEMICAL PHYSICS LETTERS | - |
dc.citation.volume | 710 | - |
dc.citation.startPage | 226 | - |
dc.citation.endPage | 233 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Physics, Atomic, Molecular & Chemical | - |
dc.subject.keywordPlus | GENOTYPE-PHENOTYPE CORRELATION | - |
dc.subject.keywordPlus | MOLECULAR-DYNAMICS | - |
dc.subject.keywordPlus | COMPLEX NETWORKS | - |
dc.subject.keywordPlus | PENDRED-SYNDROME | - |
dc.subject.keywordPlus | MOTOR PROTEIN | - |
dc.subject.keywordPlus | HEARING-LOSS | - |
dc.subject.keywordPlus | PDS GENE | - |
dc.subject.keywordPlus | PRESTIN | - |
dc.subject.keywordPlus | ENLARGEMENT | - |
dc.subject.keywordPlus | CENTRALITY | - |
dc.subject.keywordAuthor | Pendrin (SLC26A4) | - |
dc.subject.keywordAuthor | PDS | - |
dc.subject.keywordAuthor | DFNB4 | - |
dc.subject.keywordAuthor | Molecular dynamics | - |
dc.subject.keywordAuthor | Network analysis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.