Chronic Hepatitis B Infection Is Significantly Associated with Chronic Kidney Disease: a Population-based, Matched Case-control Study
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung-Eun | - |
dc.contributor.author | Jang, Eun Sun | - |
dc.contributor.author | Ki, Moran | - |
dc.contributor.author | Gwak, Geum-Youn | - |
dc.contributor.author | Kim, Kyung-Ah | - |
dc.contributor.author | Kim, Gi-Ae | - |
dc.contributor.author | Kim, Do Young | - |
dc.contributor.author | Kim, Dong Joon | - |
dc.contributor.author | Kim, Man Woo | - |
dc.contributor.author | Kim, Yun Soo | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Kim, In Hee | - |
dc.contributor.author | Kim, Chang Wook | - |
dc.contributor.author | Kim, Ho Dong | - |
dc.contributor.author | Kim, Hyung Joon | - |
dc.contributor.author | Park, Neung Hwa | - |
dc.contributor.author | Baik, Soon Koo | - |
dc.contributor.author | Suh, Jeong Ill | - |
dc.contributor.author | Song, Byung-Cheol | - |
dc.contributor.author | Song, Il Han | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Lee, Byung Seok | - |
dc.contributor.author | Lee, Youn Jae | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Chung, Woo Jin | - |
dc.contributor.author | Cho, Sung Bum | - |
dc.contributor.author | Cho, Eun-Young | - |
dc.contributor.author | Cho, Hyun Chin | - |
dc.contributor.author | Cheon, Gab Jin | - |
dc.contributor.author | Chae, Hee Bok | - |
dc.contributor.author | Choi, DaeHee | - |
dc.contributor.author | Choi, Sung-Kyu | - |
dc.contributor.author | Choi, Hwa Young | - |
dc.contributor.author | Tak, Won Young | - |
dc.contributor.author | Heo, Jeong | - |
dc.contributor.author | Jeong, Sook-Hyang | - |
dc.date.accessioned | 2021-09-02T05:09:08Z | - |
dc.date.available | 2021-09-02T05:09:08Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-10-15 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72480 | - |
dc.description.abstract | Background: Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study. Methods: A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age-and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m(2) or proteinuria as at least grade 2+ of urine protein. Results: HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m(2) (3.3%), and proteinuria (18.9%) than that of the controls (2.6%, P < 0.001, and 14.1%, P < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m(2) along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m(2). Conclusion: Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m(2) and proteinuria (>= 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | CHRONIC HBV INFECTION | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | NATIONWIDE COHORT | - |
dc.subject | VIRAL-INFECTION | - |
dc.subject | VIRUS INFECTION | - |
dc.subject | RENAL-DISEASE | - |
dc.subject | RISK | - |
dc.subject | EPIDEMIOLOGY | - |
dc.subject | GENOTYPES | - |
dc.subject | EFFICACY | - |
dc.title | Chronic Hepatitis B Infection Is Significantly Associated with Chronic Kidney Disease: a Population-based, Matched Case-control Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yeon, Jong Eun | - |
dc.contributor.affiliatedAuthor | Jung, Young Kul | - |
dc.identifier.doi | 10.3346/jkms.2018.33.e264 | - |
dc.identifier.scopusid | 2-s2.0-85054771863 | - |
dc.identifier.wosid | 000447282800003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.33, no.42 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 33 | - |
dc.citation.number | 42 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002394870 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CHRONIC HBV INFECTION | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | NATIONWIDE COHORT | - |
dc.subject.keywordPlus | VIRAL-INFECTION | - |
dc.subject.keywordPlus | VIRUS INFECTION | - |
dc.subject.keywordPlus | RENAL-DISEASE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | GENOTYPES | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordAuthor | Hepatitis B Virus | - |
dc.subject.keywordAuthor | Chronic Renal Insufficiency | - |
dc.subject.keywordAuthor | Glomerular Filtration Rate | - |
dc.subject.keywordAuthor | Proteinuria | - |
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