Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sharma, Amit | - |
dc.contributor.author | Lee, Min-Goo | - |
dc.contributor.author | Shi, Hu | - |
dc.contributor.author | Won, Miae | - |
dc.contributor.author | Arambula, Jonathan F. | - |
dc.contributor.author | Sessler, Jonathan L. | - |
dc.contributor.author | Lee, Jin Yong | - |
dc.contributor.author | Chi, Sung-Gil | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-09-02T05:10:52Z | - |
dc.date.available | 2021-09-02T05:10:52Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-10-11 | - |
dc.identifier.issn | 2451-9294 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72492 | - |
dc.description.abstract | Nearly without exception, all known cancer chemotherapeutics elicit a resistance response over time. The resulting resistance is correlated with poor clinical outcomes. Here, we report an approach to overcoming resistance through reprogramming oncogene-directed alterations in mitochondrial metabolism before drug activation while simultaneously circumventing drug efflux pumps. Conjugate Cl increases cancer cell apoptosis and inhibits regrowth of drug-resistant tumors, as inferred from efficacy studies carried out in human cancer cells and in Dox-resistant xenograft tumor models. It also displays minimal whole-animal toxicity. These benefits are ascribed to an ability to evade chemo-resistance by switching cancer cell metabolism back to normal mitochondrial oxidative phosphorylation while helping target the active Dox to first the mito-chondrion and then the nucleus. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.subject | MULTIDRUG-RESISTANCE | - |
dc.subject | METABOLIC REQUIREMENTS | - |
dc.subject | IN-VIVO | - |
dc.subject | DELIVERY | - |
dc.subject | CELLS | - |
dc.subject | MECHANISMS | - |
dc.subject | DOXORUBICIN | - |
dc.subject | GLYCOLYSIS | - |
dc.subject | STRATEGY | - |
dc.subject | RELEASE | - |
dc.title | Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Min-Goo | - |
dc.contributor.affiliatedAuthor | Won, Miae | - |
dc.contributor.affiliatedAuthor | Chi, Sung-Gil | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1016/j.chempr.2018.08.002 | - |
dc.identifier.scopusid | 2-s2.0-85052654840 | - |
dc.identifier.wosid | 000447051500019 | - |
dc.identifier.bibliographicCitation | CHEM, v.4, no.10, pp.2370 - 2383 | - |
dc.relation.isPartOf | CHEM | - |
dc.citation.title | CHEM | - |
dc.citation.volume | 4 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2370 | - |
dc.citation.endPage | 2383 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | MULTIDRUG-RESISTANCE | - |
dc.subject.keywordPlus | METABOLIC REQUIREMENTS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | GLYCOLYSIS | - |
dc.subject.keywordPlus | STRATEGY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordAuthor | bioenergetics | - |
dc.subject.keywordAuthor | cancer metabolism | - |
dc.subject.keywordAuthor | carboxylesterase | - |
dc.subject.keywordAuthor | dichloroacetic acid | - |
dc.subject.keywordAuthor | doxorubicin | - |
dc.subject.keywordAuthor | multidrug resistance | - |
dc.subject.keywordAuthor | prodrug | - |
dc.subject.keywordAuthor | SDG3: Good health and well-being | - |
dc.subject.keywordAuthor | targeted therapeutics | - |
dc.subject.keywordAuthor | Warburg effect | - |
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