Antimicrobial activity of NO-releasing compounds against periodontal pathogens
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, Ji Suk | - |
dc.contributor.author | Park, Dong-sik | - |
dc.contributor.author | Baek, Dong-Heon | - |
dc.contributor.author | Jha, Nayansi | - |
dc.contributor.author | Park, Serk In | - |
dc.contributor.author | Yun, Hyoung Jin | - |
dc.contributor.author | Kim, Won Jong | - |
dc.contributor.author | Ryu, Jae Jun | - |
dc.date.accessioned | 2021-09-02T05:15:42Z | - |
dc.date.available | 2021-09-02T05:15:42Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-10-04 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72514 | - |
dc.description.abstract | This study describes the successful synthesis of nitric oxide (NO)-releasing compounds with biodegradable and injectable properties and demonstrates that the kinetics of NO release vary according to the type of NO donor. The antimicrobial activity of NO-releasing compounds against three common periodontal pathogens, i.e., Aggregatibacter actinomy-cetemcomitans, Porphyromonas gingivalis, and Actinomyces israelii, was investigated using a susceptibility assay. Human gingival fibroblasts were treated with NO-releasing compounds at the minimum concentrations required for bacterial growth and cytotoxicity was evaluated using the MTT cell proliferation assay. Our results suggest that NO-releasing compounds can be used topically to treat both gram-negative and gram-positive periodontal pathogens. Comparison of the antimicrobial activity and cytotoxicity assay results between the NO-releasing compounds revealed that an NO donor comprising a macromolecule without surface charge, a lower instantaneous NO concentration, and an adequate supply of NO were associated with a strong bactericidal effect and low cytotoxicity. NO-releasing compounds with these properties may be suitable for treatment of periodontitis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | POTENTIAL APPLICATION | - |
dc.subject | ANTIBACTERIAL AGENTS | - |
dc.subject | DELIVERY | - |
dc.subject | DISEASES | - |
dc.subject | NANOPARTICLES | - |
dc.subject | TETRACYCLINE | - |
dc.subject | DENDRIMERS | - |
dc.subject | EFFICACY | - |
dc.title | Antimicrobial activity of NO-releasing compounds against periodontal pathogens | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Ji Suk | - |
dc.contributor.affiliatedAuthor | Park, Serk In | - |
dc.contributor.affiliatedAuthor | Ryu, Jae Jun | - |
dc.identifier.doi | 10.1371/journal.pone.0199998 | - |
dc.identifier.scopusid | 2-s2.0-85054444207 | - |
dc.identifier.wosid | 000446383500002 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.13, no.10 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | POTENTIAL APPLICATION | - |
dc.subject.keywordPlus | ANTIBACTERIAL AGENTS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | TETRACYCLINE | - |
dc.subject.keywordPlus | DENDRIMERS | - |
dc.subject.keywordPlus | EFFICACY | - |
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