Small intestine- and colon-specific smart oral drug delivery system with controlled release characteristic
DC Field | Value | Language |
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dc.contributor.author | Kang, Ji-Hye | - |
dc.contributor.author | Hwang, Ji-Young | - |
dc.contributor.author | Seo, Jae-Won | - |
dc.contributor.author | Kim, Han-Sem | - |
dc.contributor.author | Shin, Ueon Sang | - |
dc.date.accessioned | 2021-09-02T05:18:04Z | - |
dc.date.available | 2021-09-02T05:18:04Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-10-01 | - |
dc.identifier.issn | 0928-4931 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72523 | - |
dc.description.abstract | In recent years, there has been a significant increase in strategies for the development of small intestine (and colon)-specific oral drug-delivery systems to maximize the efficiency of therapeutic agents and reduce side effects. However, only a few strategies are capable of working in the complicated environment of the human intestinal tract. In this study, the preparation of a basic pH/temperature-responsive co-polymer (p-NIVIm) and its its-vitro-drug delivery function in the pH range of 1-8 and temperature range of 25-42 degrees C are reported. The basic copolymer was prepared by radical copolymerization of N-isopropyl acryl amide (NIPAAm) and N-vinylimidazole (VIm). The lower critical solution temperature (LCST) of p-NIVIm was higher in stomach pH (similar to 1.0) conditions (36.5-42 degrees C) and lower in small intestine and/or colon pH (similar to 8.0) conditions (35.8-38.2 degrees C). The ability to uptake a model protein (BSA) at body temperature and to release it in conditions of 37 degrees C and pH 1-8 was determined. The drug loading capacity (0.231 mg per 1.0 mg copolymer) and efficiency (92.4%) were high at 37 degrees C/pH 7. The drug carrier showed a slow release pattern at pH 1 (similar to 0.084 mg; similar to 35%) and then a sudden release pattern (similar to 0.177 mg; similar to 73%) at pH 8. The cytotoxicity of p-NIVIm to MCF-7 cells in vitro was minimal at concentrations < 168.9 mu g/mL after 72 h. The prepared copolymer with its pH-/temperature-responsive protein-entrapping and -releasing behavior at body temperature may potentially be applied as a novel small intestine (and colon)-specific oral drug delivery system. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | PH-RESPONSIVE POLYMERS | - |
dc.subject | MESOPOROUS SILICA | - |
dc.subject | INSULIN DELIVERY | - |
dc.subject | DEGREES-C | - |
dc.subject | COPOLYMER | - |
dc.subject | HYDROGEL | - |
dc.subject | NANOPARTICLES | - |
dc.subject | MICELLES | - |
dc.subject | CARRIERS | - |
dc.subject | THERAPY | - |
dc.title | Small intestine- and colon-specific smart oral drug delivery system with controlled release characteristic | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Ji-Young | - |
dc.identifier.doi | 10.1016/j.msec.2018.05.052 | - |
dc.identifier.scopusid | 2-s2.0-85047074562 | - |
dc.identifier.wosid | 000442192000025 | - |
dc.identifier.bibliographicCitation | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, v.91, pp.247 - 254 | - |
dc.relation.isPartOf | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | - |
dc.citation.title | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | - |
dc.citation.volume | 91 | - |
dc.citation.startPage | 247 | - |
dc.citation.endPage | 254 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | PH-RESPONSIVE POLYMERS | - |
dc.subject.keywordPlus | MESOPOROUS SILICA | - |
dc.subject.keywordPlus | INSULIN DELIVERY | - |
dc.subject.keywordPlus | DEGREES-C | - |
dc.subject.keywordPlus | COPOLYMER | - |
dc.subject.keywordPlus | HYDROGEL | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | pH- and temperature-responsive copolymer | - |
dc.subject.keywordAuthor | Oral drug-delivery systems | - |
dc.subject.keywordAuthor | Small intestine | - |
dc.subject.keywordAuthor | Colon | - |
dc.subject.keywordAuthor | Controlled delivery | - |
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