Clinical characteristics and recurrence-related factors of medication-related osteonecrosis of the jaw
DC Field | Value | Language |
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dc.contributor.author | Kang, Mong-Hun | - |
dc.contributor.author | Lee, Dong-Keon | - |
dc.contributor.author | Kim, Chang-Woo | - |
dc.contributor.author | Song, In-Seok | - |
dc.contributor.author | Jun, Sang-Ho | - |
dc.date.accessioned | 2021-09-02T05:21:08Z | - |
dc.date.available | 2021-09-02T05:21:08Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 2234-7550 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72551 | - |
dc.description.abstract | Objectives: The purpose of this study was to investigate the demographic and clinical characteristics of patients with medication-related osteonecrosis of the jaw (MRONJ) and to elucidate factors affecting recurrence in surgical treatment. Materials and Methods: A total of 51 patients who were diagnosed with MRONJ were analyzed according to demographic and clinical features and treatment results through a retrospective chart review from 2013 to 2017 in the Department of Oral and Maxillofacial Surgery Korea University Anam Hospital, Seoul in Korea. Results: Alendronate composed the majority of medication doses (55.6%), followed by ibandronate (20.0%), risedronate (15.6%), and zoledronate (6.7%). Forty patients (88.9%) were given oral medication. and five patients (11.1%) were intravenously treated, and the mean duration of medication use was 61.1 +/- 42.9 months. A total of 10 patients (22.2%) had a drug holiday before MRONJ-induced dental treatment lasting an average of 6.8:7.0 months. MRONJ occurred 2.7 times more in the mandible, with 41 cases (73.2%) occurring in the mandible and 15 cases (26.8%) occurring in the maxilla, and the prevalence of affected posterior parts (premolar-molar) was six times greater than that of the anterior parts (incisor-canine) (48 cases vs 8 cases, 85.7% vs 143%). The most common dental cause of MRONJ was tooth extraction (69.6%). Regarding recurrence. there was no statistical difference in recurrence rate according to either site or stage. However, recurrence occurred in 4 out of 34 cases (11.8%) in the primary closure group and 9 out of 20 cases (45.0%) in the secondary healing group, and there was a statistical difference with respect to closure technique. Conclusion: The identified risk factors in patients taking bone resorption inhibitors can aid dental clinicians in ensuring prevention and proper treatment of MRONJ. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD ORAL & MAXILLOFACIAL SURGERY | - |
dc.subject | BISPHOSPHONATE-RELATED OSTEONECROSIS | - |
dc.subject | SKELETAL-RELATED EVENTS | - |
dc.subject | ZOLEDRONIC ACID | - |
dc.subject | RISK-FACTORS | - |
dc.subject | SURGICAL THERAPY | - |
dc.subject | BONE METASTASES | - |
dc.subject | POSTMENOPAUSAL OSTEOPOROSIS | - |
dc.subject | MAXILLOFACIAL SURGEONS | - |
dc.subject | FOLLOW-UP | - |
dc.subject | MANAGEMENT | - |
dc.title | Clinical characteristics and recurrence-related factors of medication-related osteonecrosis of the jaw | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, In-Seok | - |
dc.identifier.doi | 10.5125/jkaoms.2018.44.5.225 | - |
dc.identifier.scopusid | 2-s2.0-85057131087 | - |
dc.identifier.wosid | 000448393500005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE KOREAN ASSOCIATION OF ORAL AND MAXILLOFACIAL SURGEONS, v.44, no.5, pp.225 - 231 | - |
dc.relation.isPartOf | JOURNAL OF THE KOREAN ASSOCIATION OF ORAL AND MAXILLOFACIAL SURGEONS | - |
dc.citation.title | JOURNAL OF THE KOREAN ASSOCIATION OF ORAL AND MAXILLOFACIAL SURGEONS | - |
dc.citation.volume | 44 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 225 | - |
dc.citation.endPage | 231 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002396148 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalWebOfScienceCategory | Dentistry, Oral Surgery & Medicine | - |
dc.subject.keywordPlus | BISPHOSPHONATE-RELATED OSTEONECROSIS | - |
dc.subject.keywordPlus | SKELETAL-RELATED EVENTS | - |
dc.subject.keywordPlus | ZOLEDRONIC ACID | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | SURGICAL THERAPY | - |
dc.subject.keywordPlus | BONE METASTASES | - |
dc.subject.keywordPlus | POSTMENOPAUSAL OSTEOPOROSIS | - |
dc.subject.keywordPlus | MAXILLOFACIAL SURGEONS | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordAuthor | Bisphophonate-associated osteonecrosis of the jaw | - |
dc.subject.keywordAuthor | Operative surgical procedure | - |
dc.subject.keywordAuthor | Recurrence | - |
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