Wogonin suppresses the LPS-enhanced invasiveness of MDA-MB-231 breast cancer cells by inhibiting the 5-LO/BLT2 cascade
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Go, Ji-Hyun | - |
dc.contributor.author | Wei, Jun-Dong | - |
dc.contributor.author | Park, Jae-In | - |
dc.contributor.author | Ahn, Kyung-Seop | - |
dc.contributor.author | Kim, Jae-Hong | - |
dc.date.accessioned | 2021-09-02T05:24:35Z | - |
dc.date.available | 2021-09-02T05:24:35Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72580 | - |
dc.description.abstract | Wogonin, a naturally occurring bioactivc monoflavonoid isolated from Scutellariae radix (roots of Scutellariae baicalensis Georgi), has known anticancer effects. However, the molecular signaling mechanism by which wogonin inhibits invasiveness in breast cancer cells remains unclear. In the present study, it was observed that wogonin exerted an inhibitory effect on the lipopolysaccharide (LPS)-enhanced invasiveness of MDA-MB-231 cells. In addition, wogonin inhibited the synthesis of interlcukin-8 (IL-8) and matrix metallopeptidase-9 (MMP-9), which are critical for promoting invasiveness in MDA-MB-231 cells. Wogonin also suppressed the expression of leukotriene B4 receptor 2 (BLT2) and the synthesis of its ligand, by inhibiting 5-lipoxygenase (5-LO) in LPS-stimulated MDA-MB-231 cells. Notably, wogonin attenuated the production of IL-8 and MMP-9 by inhibiting the BLT2/extracellular signal-regulated kinase (ERK)-linked cascade. Finally, in vivo, LPS-driven MDA-MB-231 cell metastasis was markedly suppressed by wogonin administration. Overall, the present results suggested that wogonin inhibited the 5-LO/BLT2/ERKIIL-8/MMP-9 signaling cascade and demonstrated that this cascade may be an important target through which wogonin exerts its anticancer effects in breast cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | OVARIAN-CANCER | - |
dc.subject | SCUTELLARIA-BAICALENSIS | - |
dc.subject | MCF-7 CELLS | - |
dc.subject | IN-VITRO | - |
dc.subject | INVASION | - |
dc.subject | EXPRESSION | - |
dc.subject | METASTASIS | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | PROLIFERATION | - |
dc.title | Wogonin suppresses the LPS-enhanced invasiveness of MDA-MB-231 breast cancer cells by inhibiting the 5-LO/BLT2 cascade | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hong | - |
dc.identifier.doi | 10.3892/ijmm.2018.3776 | - |
dc.identifier.scopusid | 2-s2.0-85052380883 | - |
dc.identifier.wosid | 000442971000013 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.42, no.4, pp.1899 - 1908 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.volume | 42 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1899 | - |
dc.citation.endPage | 1908 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | SCUTELLARIA-BAICALENSIS | - |
dc.subject.keywordPlus | MCF-7 CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordAuthor | wogonin | - |
dc.subject.keywordAuthor | lipopolysaccharide | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | MDA-MB-231 cells | - |
dc.subject.keywordAuthor | invasiveness | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | 5-lipoxygenase | - |
dc.subject.keywordAuthor | leukotriene B4 receptor 2 | - |
dc.subject.keywordAuthor | inteleukin-8 | - |
dc.subject.keywordAuthor | matrix metallopeptidase-9 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.