Treadmill exercise improves memory function by inhibiting hippocampal apoptosis in pilocarpine-induced epileptic rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jae-Min | - |
dc.contributor.author | Ji, Eun-Sang | - |
dc.contributor.author | Kim, Tae-Woon | - |
dc.contributor.author | Kim, Chang-Ju | - |
dc.contributor.author | Shin, Mal-Soon | - |
dc.contributor.author | Lim, Baek-Vin | - |
dc.contributor.author | Chung, Yong-Rak | - |
dc.contributor.author | Cho, Young Sam | - |
dc.date.accessioned | 2021-09-02T05:29:30Z | - |
dc.date.available | 2021-09-02T05:29:30Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 2288-176X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72622 | - |
dc.description.abstract | Epilepsy is characterized by recurrent seizures and loss of neurons with abnormal rhythmic firing in the brains. In the present study, we investigated the effect of treadmill exercise on memory function in relation with cell proliferation and apoptosis in the hippocampus using pilocarpine-induced seizure rats. Epilepsy was initiated by intraperitoneal injection of pilocarpine hydrochloride. The rats in the exercise group were forced to run on a motorized treadmill for 30 min once a day for 2 weeks. In the present results, treadmill exercise alleviated short-term and spatial learning memory impairments in the epileptic rats. Treadmill exercise suppressed neuronal degeneration and enhanced neuronal maturation in the epileptic rats. Treadmill exercise suppressed cell proliferation and apoptosis in the epileptic rats. Treadmill exercise alleviated pilocarpine-induced memory impairments and suppressed neuronal loss in the hippocampus through down-regulation of apoptosis. These findings offer a possibility that treadmill exercise may provide a preventive or therapeutic value to the epilepsy-induced learning and memory impairments. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC EXERCISE REHABILITATION | - |
dc.subject | SEIZURE-INDUCED NEUROGENESIS | - |
dc.subject | SHORT-TERM-MEMORY | - |
dc.subject | ENHANCING NEUROGENESIS | - |
dc.subject | SUPPRESSING APOPTOSIS | - |
dc.subject | NEURONAL MATURATION | - |
dc.subject | CELL-PROLIFERATION | - |
dc.subject | IMPAIRMENT | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | MODULATION | - |
dc.subject | ACTIVATION | - |
dc.title | Treadmill exercise improves memory function by inhibiting hippocampal apoptosis in pilocarpine-induced epileptic rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Mal-Soon | - |
dc.identifier.doi | 10.12965/jer.36394.197 | - |
dc.identifier.scopusid | 2-s2.0-85056775010 | - |
dc.identifier.wosid | 000448629600003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXERCISE REHABILITATION, v.14, no.5, pp.713 - 723 | - |
dc.relation.isPartOf | JOURNAL OF EXERCISE REHABILITATION | - |
dc.citation.title | JOURNAL OF EXERCISE REHABILITATION | - |
dc.citation.volume | 14 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 713 | - |
dc.citation.endPage | 723 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Rehabilitation | - |
dc.relation.journalWebOfScienceCategory | Rehabilitation | - |
dc.subject.keywordPlus | SEIZURE-INDUCED NEUROGENESIS | - |
dc.subject.keywordPlus | SHORT-TERM-MEMORY | - |
dc.subject.keywordPlus | ENHANCING NEUROGENESIS | - |
dc.subject.keywordPlus | SUPPRESSING APOPTOSIS | - |
dc.subject.keywordPlus | NEURONAL MATURATION | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Epilepsy | - |
dc.subject.keywordAuthor | Treadmill exercise | - |
dc.subject.keywordAuthor | Short-term memory | - |
dc.subject.keywordAuthor | Spatial learning memory | - |
dc.subject.keywordAuthor | Cell proliferation | - |
dc.subject.keywordAuthor | Apoptosis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.