Genetic Association between Serum 25-Hydroxyvitamin D Levels and Lung Function in Korean Men and Women: Data from KNHANES 2011-2012
DC Field | Value | Language |
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dc.contributor.author | Park, Clara Yongjoo | - |
dc.contributor.author | Kwak, So-Young | - |
dc.contributor.author | Jo, Garam | - |
dc.contributor.author | Shin, Min-Jeong | - |
dc.date.accessioned | 2021-09-02T05:34:29Z | - |
dc.date.available | 2021-09-02T05:34:29Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72658 | - |
dc.description.abstract | The association between single-nucleotide polymorphisms (SNPs) in the vitamin D metabolic pathway and lung function is unknown. We examined the association between five SNPs on DHCR7, GC, CYP2R1, and CYP24A1 along with serum 25-hydroxyvitamin D (25(OH)D) levels and lung function in older Korean men (n = 758) and women (n = 837). Lung function was determined by forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) from the data in the Korea Nutrition and Health Examination Survey 2011-2012. Genetic risk score (GRS) was calculated by the number of 25(OH)D-decreasing alleles of the five SNPs. Our results showed that increases in GRS were associated with reduced 25(OH)D levels (p < 0.05 for both sexes). In the entire population, FVC and FEV1 were associated with both GRS and 25(OH)D levels. In women, FVC and FEV1 were negatively associated with GRS (beta-coefficient (95% CI): -0.022 (-0.039, -0.005) and -0.020 (-0.035, -0.005), respectively; both p < 0.05), but not with 25(OH)D. However, in men, FVC and FEV1 were positively associated with 25(OH)D (beta-coefficient (95% CI): 0.008 (0.001, 0.016) and 0.008 (0.002, 0.015), respectively; both p < 0.05), but not with GRS. In conclusion, lung function was associated with genetic variation in Korean women and with 25(OH)D in Korean men. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | D-BINDING PROTEIN | - |
dc.subject | OBSTRUCTIVE PULMONARY-DISEASE | - |
dc.subject | NUTRITION EXAMINATION SURVEY | - |
dc.subject | VITAMIN-D STATUS | - |
dc.subject | GENOME-WIDE ASSOCIATION | - |
dc.subject | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject | NATIONAL-HEALTH | - |
dc.subject | MENDELIAN RANDOMIZATION | - |
dc.subject | ENVIRONMENTAL-FACTORS | - |
dc.subject | AFRICAN-AMERICANS | - |
dc.title | Genetic Association between Serum 25-Hydroxyvitamin D Levels and Lung Function in Korean Men and Women: Data from KNHANES 2011-2012 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Min-Jeong | - |
dc.identifier.doi | 10.3390/nu10101362 | - |
dc.identifier.scopusid | 2-s2.0-85053816081 | - |
dc.identifier.wosid | 000448821300028 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.10, no.10 | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | D-BINDING PROTEIN | - |
dc.subject.keywordPlus | OBSTRUCTIVE PULMONARY-DISEASE | - |
dc.subject.keywordPlus | NUTRITION EXAMINATION SURVEY | - |
dc.subject.keywordPlus | VITAMIN-D STATUS | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | NATIONAL-HEALTH | - |
dc.subject.keywordPlus | MENDELIAN RANDOMIZATION | - |
dc.subject.keywordPlus | ENVIRONMENTAL-FACTORS | - |
dc.subject.keywordPlus | AFRICAN-AMERICANS | - |
dc.subject.keywordAuthor | vitamin D | - |
dc.subject.keywordAuthor | single-nucleotide polymorphism | - |
dc.subject.keywordAuthor | KNHANES | - |
dc.subject.keywordAuthor | lung function | - |
dc.subject.keywordAuthor | FVC | - |
dc.subject.keywordAuthor | FEV1 | - |
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