Lipid-Reactive T Cells in Immunological Disorders of the Lung
- Authors
- Ryu, Seungwon; Park, Joon Seok; Kim, Hye Young; Kim, Ji Hyung
- Issue Date
- 26-9월-2018
- Publisher
- FRONTIERS MEDIA SA
- Keywords
- pulmonary disorders; lipid antigens; CD1 molecules; CD1-restricted T cells; natural killer T cells
- Citation
- FRONTIERS IN IMMUNOLOGY, v.9
- Indexed
- SCIE
SCOPUS
- Journal Title
- FRONTIERS IN IMMUNOLOGY
- Volume
- 9
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/73055
- DOI
- 10.3389/fimmu.2018.02205
- ISSN
- 1664-3224
- Abstract
- Regulation of T cell-mediated immunity in the lungs is critical for prevention of immune-related lung disorders and for host protection from pathogens. While the prevalent view of pulmonary T cell responses is based on peptide recognition by antigen receptors, called T cell receptors (TCR), on the T cell surface in the context of classical major histocompatibility complex (MHC) molecules, novel pathways involving the presentation of lipid antigens by cluster of differentiation 1 (CD1) molecules to lipid-reactive T cells are emerging as key players in pulmonary immune system. Whereas, genetic conservation of group II CD1 (CD1d) in mouse and human genomes facilitated numerous in vivo studies of CD1d-restricted invariant natural killer T (i NKT) cells in lung diseases, the recent development of human CD1-transgenic mice has made it possible to examine the physiological roles of group I CD1 (CD1a-c) molecules in lung immunity. Here, we discuss current understanding of the biology of CD1-reactive T cells with a specific focus on their roles in several pulmonary disorders.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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