Implantable Photothermal Agents based on Gold Nanorods-Encapsulated Microcube
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Hyun June | - |
dc.contributor.author | Ku, Minhee | - |
dc.contributor.author | Lee, Hyunjee | - |
dc.contributor.author | Yoon, Nara | - |
dc.contributor.author | Yang, Jaemoon | - |
dc.contributor.author | Bong, Ki Wan | - |
dc.date.accessioned | 2021-09-02T06:27:28Z | - |
dc.date.available | 2021-09-02T06:27:28Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-09-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73112 | - |
dc.description.abstract | Gold nanorods (GNRs) are of great interest in cancer therapy given their ability to ablate tumor cells using deep tissue-penetrating near-infrared light. GNRs coated with tumor-specific moieties have the potential to target tumor tissue to minimize damage to normal tissue. However, perfect targeting is difficult to achieve given that nanoparticles could be broadly dispersed inside the body. Moreover, interaction between targeting groups and biological molecules could lower targeting abilities, resulting in off-target accumulation which might produce nanotoxicity. Here we introduce GNR-encapsulated microcubes (GNR@MCs) that can be utilized as implantable photothermal agents. GNR@MCs are created by encapsulating GNRs in polymeric networks via stop flow lithography (SFL), a one-phase synthesis technique which allows for creation of surfactant-free, uniform particles, and injection of GNR@MCs into the body after a simple rinse step. GNRs are highly packed and firmly encapsulated inside MCs, and entrapped GNRs exhibit optical properties comparable to that of unbound GNRs and photothermal efficiency (58%) in line with that of nano-sized agents (51-95%). Photothermal ablation in murine models is achieved using GNR@MCs stably implanted into the tumor tissue, which suggests that GNR@MCs can be a safe and effective platform for cancer therapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | STOP-FLOW LITHOGRAPHY | - |
dc.subject | NANOPARTICLES | - |
dc.subject | MICROPARTICLES | - |
dc.subject | RELEASE | - |
dc.subject | CYTOTOXICITY | - |
dc.subject | PARTICLES | - |
dc.subject | DOSIMETRY | - |
dc.subject | TOXICITY | - |
dc.subject | SIZE | - |
dc.title | Implantable Photothermal Agents based on Gold Nanorods-Encapsulated Microcube | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bong, Ki Wan | - |
dc.identifier.doi | 10.1038/s41598-018-31793-9 | - |
dc.identifier.scopusid | 2-s2.0-85053208162 | - |
dc.identifier.wosid | 000444377500003 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.8 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | STOP-FLOW LITHOGRAPHY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | MICROPARTICLES | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | DOSIMETRY | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | SIZE | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.