Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ji-Hye | - |
dc.contributor.author | Lee, Jun Mi | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.contributor.author | Kim, Kwang Rok | - |
dc.date.accessioned | 2021-09-02T06:27:55Z | - |
dc.date.available | 2021-09-02T06:27:55Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-09-10 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73116 | - |
dc.description.abstract | Sirtuins, a family of NAD(+)-dependent deacetylase enzymes, have been identified as mammalian homologs of yeast silent information regulator 2 (SIR2). Sirtuin 6 (SIRT6) plays important roles in cell homeostasis, DNA damage repair, cancer suppression, and aging. SIRT6 overexpression improves metabolic diseases, such as hypercholesterolemia, cholesterol-related disease, and type 2 diabetes via AMP-activated protein kinase (AMPK) activation. SIRT6 is abundant in the liver and is a crucial target for patients with liver steatosis. Compounds for drug repositioning were screened to identify potential SIRT6 activators, and fluvastatin, a synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase that reduces cholesterol synthesis, was identified to activate SIRT6. When HepG2 cells were treated with fluvastatin, the expression of SIRT6 and phosphorylation of sterol regulatory element-binding protein (SREBP)-1 and AMPK alpha, which is regulated by SIRT6, increased. In this study, we examined the mechanism underlying cholesterol regulation by fluvastatin via SREBP-1 and AMPK alpha pathway and suggested that fluvastatin is an SIRT6 activator that regulates cholesterol homeostasis and fatty liver disease. (C) 2018 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | FATTY LIVER | - |
dc.subject | LIPID-ACCUMULATION | - |
dc.subject | IN-VIVO | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | MICE | - |
dc.subject | HEPATOCYTES | - |
dc.subject | DEACETYLASE | - |
dc.subject | METABOLISM | - |
dc.subject | STEATOSIS | - |
dc.title | Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hoon | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.07.057 | - |
dc.identifier.scopusid | 2-s2.0-85050851678 | - |
dc.identifier.wosid | 000444222100035 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.503, no.3, pp.1415 - 1421 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 503 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1415 | - |
dc.citation.endPage | 1421 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | FATTY LIVER | - |
dc.subject.keywordPlus | LIPID-ACCUMULATION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | HEPATOCYTES | - |
dc.subject.keywordPlus | DEACETYLASE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | STEATOSIS | - |
dc.subject.keywordAuthor | SIRT6 | - |
dc.subject.keywordAuthor | Fluvastatin | - |
dc.subject.keywordAuthor | SREBP-1 | - |
dc.subject.keywordAuthor | AMP-Activated protein kinase alpha | - |
dc.subject.keywordAuthor | Nonalcoholic fatty liver disease | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.