Systemic Juvenile Xanthogranuloma Involving the Bone Marrow, Multiple Bones, and the Skin That Developed During Treatment of Acute Lymphoblastic Leukemia in Remission State
DC Field | Value | Language |
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dc.contributor.author | Cheon, Eunjae | - |
dc.contributor.author | Yang, Saemi | - |
dc.contributor.author | Han, Jae Ho | - |
dc.contributor.author | Lee, Kwang Chul | - |
dc.contributor.author | Park, Jun Eun | - |
dc.date.accessioned | 2021-09-02T06:33:26Z | - |
dc.date.available | 2021-09-02T06:33:26Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 1093-5266 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73165 | - |
dc.description.abstract | Juvenile xanthogranuloma (JXG) is a rare benign disorder classified as non-Langerhans cell histiocytosis, with unclear etiology and pathogenesis. JXG is generally characterized by solitary or multiple cutaneous nodules that resolve spontaneously over a few years. JXG rarely presents as extracutaneous lesions that progress to a symptomatic systemic disorder through multiple organ involvement. We encountered a systemic JXG case involving the bone marrow, multiple bones, and the skin during acute lymphoblastic leukemia (ALL) treatment. A 16-year-old boy undergoing ALL treatment experienced unexplained prolonged fever and scalp, hip joint, and right knee joint pain for 2 weeks during interim maintenance chemotherapy. Bone marrow pathologic findings revealed no evidence of leukemia relapse but showed diffuse infiltration of histiocytes with several Touton-type giant cells; the stains were positive for CD68 and negative for CD1a and S100 protein. Bone and skin biopsies confirmed the findings. Symptoms have resolved since maintenance chemotherapy, which included vincristine, dexamethasone, 6-mercaptopurine, and methotrexate. Bone marrow involvement of JXG is very rare, occurring only in patients less than 1 year of age; however, this case was reported in an adolescent during ALL treatment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.subject | NEUROFIBROMATOSIS | - |
dc.subject | ASSOCIATION | - |
dc.subject | LIVER | - |
dc.title | Systemic Juvenile Xanthogranuloma Involving the Bone Marrow, Multiple Bones, and the Skin That Developed During Treatment of Acute Lymphoblastic Leukemia in Remission State | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Chul | - |
dc.identifier.doi | 10.1177/1093526617721775 | - |
dc.identifier.scopusid | 2-s2.0-85053913389 | - |
dc.identifier.wosid | 000454230700011 | - |
dc.identifier.bibliographicCitation | PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, v.21, no.5, pp.489 - 493 | - |
dc.relation.isPartOf | PEDIATRIC AND DEVELOPMENTAL PATHOLOGY | - |
dc.citation.title | PEDIATRIC AND DEVELOPMENTAL PATHOLOGY | - |
dc.citation.volume | 21 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 489 | - |
dc.citation.endPage | 493 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | NEUROFIBROMATOSIS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordAuthor | juvenile xanthogranuloma | - |
dc.subject.keywordAuthor | systemic | - |
dc.subject.keywordAuthor | bone marrow | - |
dc.subject.keywordAuthor | lymphoblastic leukemia | - |
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