Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Heo, Jee-In | - |
dc.contributor.author | Yoon, Dae Wui | - |
dc.contributor.author | Yu, Ji Hee | - |
dc.contributor.author | Kim, Nam Hoon | - |
dc.contributor.author | Yoo, Hye Jin | - |
dc.contributor.author | Seo, Ji A. | - |
dc.contributor.author | Kim, Sin Gon | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Choi, Dong Seop | - |
dc.contributor.author | Kim, Nan Hee | - |
dc.date.accessioned | 2021-09-02T07:23:24Z | - |
dc.date.available | 2021-09-02T07:23:24Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 0742-3098 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73627 | - |
dc.description.abstract | Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The 2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA), are one of the hepatokines and are known to be associated with insulin resistance and type 2 diabetes. The aim of this study was to determine whether melatonin improves hepatic insulin resistance and hepatic steatosis in a FETUA-dependent manner. In HepG2 cells treated with 300mol/L of palmitic acid, phosphorylated AKT expression decreased, and FETUA expression increased, but this effect was inhibited by treatment with 10mol/L of melatonin. However, melatonin did not improve insulin resistance in FETUA-overexpressing cells, indicating that improvement in insulin resistance by melatonin was dependent on downregulation of FETUA. Moreover, melatonin decreased palmitic acid-induced ER stress markers, CHOP, Bip, ATF-6, XBP-1, ATF-4, and PERK. In addition, in the high-fat diet (HFD) mice, oral treatment with 100mg/kg/day melatonin for 10weeks reduced body weight gain to one-third of that of the HFD group and hepatic steatosis. Insulin sensitivity and glucose intolerance improved with the upregulation of muscle p-AKT protein expression. FETUA expression and ER stress markers in the liver and serum of HFD mice were decreased by melatonin treatment. In conclusion, melatonin can improve hepatic insulin resistance and hepatic steatosis through reduction in ER stress and the resultant AHSG expression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | FATTY LIVER-DISEASE | - |
dc.subject | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject | FETUIN-A | - |
dc.subject | PLASMA-LEVELS | - |
dc.subject | NONALCOHOLIC STEATOHEPATITIS | - |
dc.subject | BLOOD-PRESSURE | - |
dc.subject | WEIGHT-GAIN | - |
dc.subject | RATS | - |
dc.subject | DIET | - |
dc.subject | METABOLISM | - |
dc.title | Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Heo, Jee-In | - |
dc.contributor.affiliatedAuthor | Yu, Ji Hee | - |
dc.contributor.affiliatedAuthor | Kim, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Jin | - |
dc.contributor.affiliatedAuthor | Seo, Ji A. | - |
dc.contributor.affiliatedAuthor | Kim, Sin Gon | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Dong Seop | - |
dc.contributor.affiliatedAuthor | Kim, Nan Hee | - |
dc.identifier.doi | 10.1111/jpi.12493 | - |
dc.identifier.scopusid | 2-s2.0-85045845779 | - |
dc.identifier.wosid | 000441133600004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PINEAL RESEARCH, v.65, no.2 | - |
dc.relation.isPartOf | JOURNAL OF PINEAL RESEARCH | - |
dc.citation.title | JOURNAL OF PINEAL RESEARCH | - |
dc.citation.volume | 65 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | FATTY LIVER-DISEASE | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | FETUIN-A | - |
dc.subject.keywordPlus | PLASMA-LEVELS | - |
dc.subject.keywordPlus | NONALCOHOLIC STEATOHEPATITIS | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | WEIGHT-GAIN | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | DIET | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordAuthor | ER stress | - |
dc.subject.keywordAuthor | fetuin-A | - |
dc.subject.keywordAuthor | insulin resistance | - |
dc.subject.keywordAuthor | melatonin | - |
dc.subject.keywordAuthor | nonalcoholic fatty liver disease | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.