Intensive blood pressure control may not be safe in subacute ischemic stroke by intracranial atherosclerosis: a result of randomized trial
- Authors
- Park, Jong-Moo; Kim, Bum Joon; Kwon, Sun U.; Hwang, Yang-Ha; Heo, Sung Hyuk; Rha, Joung-Ho; Lee, Jun; Park, Man-Seok; Kim, Joon-Tae; Song, Hee-Jung; Park, Jong-Ho; Yu, Sungwook; Lee, Soo Joo; Park, Tai Hwan; Cha, Jae-Kwan; Kwon, Hyung-Min; Kim, Eung-Gyu; Lee, Seung-Hoon; Lee, Ji Sung; Lee, Juneyoung
- Issue Date
- 9월-2018
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- hypertension; intracranial atherosclerosis; secondary prevention
- Citation
- JOURNAL OF HYPERTENSION, v.36, no.9, pp.1936 - 1941
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF HYPERTENSION
- Volume
- 36
- Number
- 9
- Start Page
- 1936
- End Page
- 1941
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/73665
- DOI
- 10.1097/HJH.0000000000001784
- ISSN
- 0263-6352
- Abstract
- Objective:Current guideline recommends intensive blood pressure (BP) control in hypertensive patients, but the appropriate target BP level after ischemic stroke due to intracranial atherosclerotic stenosis remains uncertain.Methods:In this randomized, single-blinded trial, patients with symptomatic internal carotid or middle cerebral artery steno-occlusion (>50%) within 7-42 days after index stroke received intensive (target SBP<120mmHg) or modest (target SBP<140mmHg) BP control from April 2010 to December 2012. The primary outcome was the change in ischemic lesion volume in white matter lesions at the whole forebrain between baseline and 24 weeks as measured from fluid attenuation inversion recovery (FLAIR) images, which was tested in noninferiority test (noninferiority margin of 3cm(3)).Results:Among 132 patients, follow-up FLAIR images were available in 111 (59 in the intensive and 52 in the moderate BP control groups). After 24 weeks, the SBP in the intensive group was significantly lower (124.610.5mmHg) than in the modest group (132.3 +/- 10.6mmHg). The ischemic lesion volume increased more in the intensive group (4.9 +/- 18.3cm(3)) than the modest group (2.2 +/- 8.2cm(3)), which failed to prove noninferiority. The frequency of new ischemic lesions on 24-week FLAIR images was nonsignificantly higher in the intensive group than the modest group [10 (16.9%) vs. 5 (9.6%), respectively; P=0.26)]. Only one recurrent stroke developed during the study period in each group.Conclusion:Intensive BP control in intracranial atherosclerotic stenosis patients failed to prove noninferiority compared with modest BP control, and may increase ischemic lesion volume in the subacute stage.
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