Hemoglobin as a Diagnosing Molecule for Biological Effects of Atmospheric-Pressure Plasma
- Authors
- Ki, Se Hoon; Sin, Somin; Shin, Jae-Ho; Kwon, Young Wan; Chae, Myoung Won; Uhm, Han Sup; Baik, Ku Youn; Choi, Eun Ha
- Issue Date
- 9월-2018
- Publisher
- SPRINGER
- Keywords
- Atmospheric pressure plasma; Hemoglobin; Reactive oxygen species (ROS); Reactive nitrogen species (RNS); ROS/RNS scavengers
- Citation
- PLASMA CHEMISTRY AND PLASMA PROCESSING, v.38, no.5, pp.937 - 952
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLASMA CHEMISTRY AND PLASMA PROCESSING
- Volume
- 38
- Number
- 5
- Start Page
- 937
- End Page
- 952
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/73669
- DOI
- 10.1007/s11090-018-9917-z
- ISSN
- 0272-4324
- Abstract
- The studies with proteins are necessary to understand the biological effects of atmospheric pressure plasma (APP). Among proteins, those with transient metal ions play key roles in many biological events and they are very sensitive to environmental redox states. Iron-containing hemoglobin (Hb) is investigated in this study, after APP treatments under two environmental gas conditions of pure N-2 and N-2 + O-2 mixture. Monitoring the intensity change for absorption spectra could lead to a quantitative assessment of the effect of discharge plasma on Hb. Redox states of Hb are classified into five states including O-2-bound Hb (oxy-Hb), deoxy-Hb, met-Hb, NO-bound Hb (NO-Hb), and hemichrome. Chemically generated reactive species and some scavengers are applied to understand the chemical reactions. Our experimental results confirm the complex chemical reactions of APP and suggest the possible use of Hb as a model protein for the visualization of APP biological effects.
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Collections - Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles
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