Vitamin D level and risk of systemic lupus erythematosus and rheumatoid arthritis: a Mendelian randomization
DC Field | Value | Language |
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dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-02T07:30:44Z | - |
dc.date.available | 2021-09-02T07:30:44Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 0770-3198 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73681 | - |
dc.description.abstract | The aim of this study was to examine whether the vitamin D level is causally associated with risk of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). We performed two-sample Mendelian randomization (MR) analyses using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods on publicly available summary statistics datasets using two vitamin D level genome-wide association studies (GWASs) as exposure and SLE and RA GWASs on people of European descent as outcomes. We selected three independent single-nucleotide polymorphisms located at SSTR4 (rs2207173), GC (rs2282679), and NADSYN1 (3829251) with gnome-wide significance from two GWASs on vitamin D levels as instrumental variables. The IVW, weighted median, and MR-Egger regression methods yielded no evidence of a causal association between vitamin D level and risk of SLE (beta = 0.032, SE = 0.119, p = 0.789; beta = 0.233, SE = 0.274, p = 0.552; beta = 0.054, SE = 0.125, p = 0.665; respectively) or RA (beta = 0.026, SE = 0.061, p = 0.664; beta = 0.025, SE = 0.065, p = 0.695; beta = 0.025, SE = 0.065, p = 0.695; respectively). In addition, MR-Egger regression revealed directional pleiotropy was unlikely to be biasing the result for SLE (intercept = - 0.058, p = 0.545) or RA (intercept = - 0.027, p = 0.558). The MR estimates from IVW, weighted median, and MR-Egger regression analyses were consistent. MR analysis did not support a causal association between the vitamin D level and SLE or RA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER LONDON LTD | - |
dc.subject | GENOME-WIDE ASSOCIATION | - |
dc.subject | AUTOIMMUNE-DISEASE | - |
dc.subject | INSTRUMENTS | - |
dc.subject | DEFICIENCY | - |
dc.subject | BIAS | - |
dc.title | Vitamin D level and risk of systemic lupus erythematosus and rheumatoid arthritis: a Mendelian randomization | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1007/s10067-018-4152-9 | - |
dc.identifier.scopusid | 2-s2.0-85047341952 | - |
dc.identifier.wosid | 000441845200013 | - |
dc.identifier.bibliographicCitation | CLINICAL RHEUMATOLOGY, v.37, no.9, pp.2415 - 2421 | - |
dc.relation.isPartOf | CLINICAL RHEUMATOLOGY | - |
dc.citation.title | CLINICAL RHEUMATOLOGY | - |
dc.citation.volume | 37 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2415 | - |
dc.citation.endPage | 2421 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | AUTOIMMUNE-DISEASE | - |
dc.subject.keywordPlus | INSTRUMENTS | - |
dc.subject.keywordPlus | DEFICIENCY | - |
dc.subject.keywordPlus | BIAS | - |
dc.subject.keywordAuthor | Mendelian randomization | - |
dc.subject.keywordAuthor | RA | - |
dc.subject.keywordAuthor | SLE | - |
dc.subject.keywordAuthor | Telomere length | - |
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