Elevated interleukin-6 and bronchiectasis as risk factors for acute exacerbation in patients with tuberculosis-destroyed lung with airflow limitation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Jee Youn | - |
dc.contributor.author | Lee, Young Seok | - |
dc.contributor.author | Min, Kyung Hoon | - |
dc.contributor.author | Hur, Gyu Young | - |
dc.contributor.author | Lee, Sung Yong | - |
dc.contributor.author | Kang, Kyung Ho | - |
dc.contributor.author | Rhee, Chin Kook | - |
dc.contributor.author | Park, Seoung Ju | - |
dc.contributor.author | Shim, Jae Jeong | - |
dc.date.accessioned | 2021-09-02T07:31:33Z | - |
dc.date.available | 2021-09-02T07:31:33Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 2072-1439 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73688 | - |
dc.description.abstract | Background: Patients with tuberculosis-destroyed lungs (TDLs), with airflow limitation, have clinical characteristics similar to those of patients with chronic obstructive pulmonary disease (COPD). Acute exacerbation is an important factor in the management of TDL. Therefore, the aim of this study was to investigate the factors associated with acute exacerbations in patients with stable TDL with airflow limitation. Methods: We evaluated the clinical characteristics, such as lung function, image findings, and serum laboratory findings, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and interleukin (IL)-6, in patients with TDL with chronic airflow limitation (n= 94). We evaluated the correlation of these parameters with acute exacerbation. Results: We found that patients with exacerbation were more likely to have bronchiectasis than those without exacerbation (patients with exacerbation, 66.7%; patients without exacerbation, 30.5%; P=0.001). CRP and IL-6 levels were significantly higher in patients with exacerbation than in those without exacerbation (P=0.001 and P<0.001, respectively). Bronchiectasis [OR, 3.248; 95% confidence interval (CI), 1.063-9.928; P=0.039] and elevated IL-6 levels (OR, 1.128; 95% CI, 1.013-1.257; P=0.028) were the most important parameters associated with acute exacerbation in patients with TDL with airflow limitation. Conclusions: Patients with bronchiectasis and high IL-6 levels may require more intensive treatment to prevent acute exacerbation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AME PUBL CO | - |
dc.subject | FUNCTION DECLINE | - |
dc.subject | DISEASE | - |
dc.subject | BIOMARKERS | - |
dc.subject | MORTALITY | - |
dc.subject | OUTCOMES | - |
dc.subject | CT | - |
dc.title | Elevated interleukin-6 and bronchiectasis as risk factors for acute exacerbation in patients with tuberculosis-destroyed lung with airflow limitation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Jee Youn | - |
dc.contributor.affiliatedAuthor | Min, Kyung Hoon | - |
dc.contributor.affiliatedAuthor | Hur, Gyu Young | - |
dc.contributor.affiliatedAuthor | Lee, Sung Yong | - |
dc.contributor.affiliatedAuthor | Kang, Kyung Ho | - |
dc.contributor.affiliatedAuthor | Shim, Jae Jeong | - |
dc.identifier.doi | 10.21037/jtd.2018.08.29 | - |
dc.identifier.scopusid | 2-s2.0-85054525690 | - |
dc.identifier.wosid | 000445930200020 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THORACIC DISEASE, v.10, no.9, pp.5246 - 5253 | - |
dc.relation.isPartOf | JOURNAL OF THORACIC DISEASE | - |
dc.citation.title | JOURNAL OF THORACIC DISEASE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 5246 | - |
dc.citation.endPage | 5253 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | FUNCTION DECLINE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordAuthor | Bronchiectasis | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | interleukin (IL)-6 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.