Modulating the GSH/Trx selectivity of a fluorogenic disulfide-based thiol sensor to reveal diminished GSH levels under ER stress
DC Field | Value | Language |
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dc.contributor.author | Wi, Youngjin | - |
dc.contributor.author | Le, Hoa Thi | - |
dc.contributor.author | Verwilst, Peter | - |
dc.contributor.author | Sunwoo, Kyoung | - |
dc.contributor.author | Kim, Seo Jin | - |
dc.contributor.author | Song, Jung Eun | - |
dc.contributor.author | Yoon, Hey Young | - |
dc.contributor.author | Han, Geon | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.contributor.author | Kang, Chulhun | - |
dc.contributor.author | Kim, Tae Woo | - |
dc.date.accessioned | 2021-09-02T07:39:17Z | - |
dc.date.available | 2021-09-02T07:39:17Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-08-18 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73750 | - |
dc.description.abstract | We synthesized a fluorogenic disulfide-based naphthalimide thiol probe (ER-Naph) with a hydrophilic endoplasmic reticulum (ER)-guiding glibenclamide unit. Its ER targeting ability and high selectivity to GSH over thioredoxin, a potent competitor, were clearly demonstrated, both in solution and in vitro. Finally, a confocal microscopic investigation revealed that GSH levels in the ER were dramatically decreased under thapsigargin, brefeldin A, and tunicamycin-induced ER stress models. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | ON FLUORESCENT-PROBE | - |
dc.subject | ENDOPLASMIC-RETICULUM | - |
dc.subject | GLUTATHIONE | - |
dc.subject | THIOREDOXIN | - |
dc.subject | CYSTEINE | - |
dc.subject | CELLS | - |
dc.subject | MITOCHONDRIA | - |
dc.subject | HOMOCYSTEINE | - |
dc.subject | INHIBITION | - |
dc.subject | SYSTEM | - |
dc.title | Modulating the GSH/Trx selectivity of a fluorogenic disulfide-based thiol sensor to reveal diminished GSH levels under ER stress | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1039/c8cc04846k | - |
dc.identifier.scopusid | 2-s2.0-85051273116 | - |
dc.identifier.wosid | 000441027700024 | - |
dc.identifier.bibliographicCitation | CHEMICAL COMMUNICATIONS, v.54, no.64, pp.8897 - 8900 | - |
dc.relation.isPartOf | CHEMICAL COMMUNICATIONS | - |
dc.citation.title | CHEMICAL COMMUNICATIONS | - |
dc.citation.volume | 54 | - |
dc.citation.number | 64 | - |
dc.citation.startPage | 8897 | - |
dc.citation.endPage | 8900 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | ON FLUORESCENT-PROBE | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | THIOREDOXIN | - |
dc.subject.keywordPlus | CYSTEINE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | HOMOCYSTEINE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | SYSTEM | - |
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