Intracellular interleukin-32 gamma mediates antiviral activity of cytokines against hepatitis B virus
DC Field | Value | Language |
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dc.contributor.author | Kim, Doo Hyun | - |
dc.contributor.author | Park, Eun-Sook | - |
dc.contributor.author | Lee, Ah Ram | - |
dc.contributor.author | Park, Soree | - |
dc.contributor.author | Park, Yong Kwang | - |
dc.contributor.author | Ahn, Sung Hyun | - |
dc.contributor.author | Kang, Hong Seok | - |
dc.contributor.author | Won, Ju Hee | - |
dc.contributor.author | Ha, Yea Na | - |
dc.contributor.author | Jae, ByeongJune | - |
dc.contributor.author | Kim, Dong-Sik | - |
dc.contributor.author | Chung, Woo-Chang | - |
dc.contributor.author | Song, Moon Jung | - |
dc.contributor.author | Kim, Kee-Hwan | - |
dc.contributor.author | Park, Seung Hwa | - |
dc.contributor.author | Kim, Soo-Hyun | - |
dc.contributor.author | Kim, Kyun-Hwan | - |
dc.date.accessioned | 2021-09-02T07:39:57Z | - |
dc.date.available | 2021-09-02T07:39:57Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-08-16 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73756 | - |
dc.description.abstract | Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-gamma in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription and replication. The gamma isoform of IL-32 (IL-32 gamma) inhibits viral enhancer activities by downregulating liver-enriched transcription factors. Our data are validated in both an in vivo HBV mouse model and primary human hepatocytes. This study thus suggests that IL-32 gamma functions as intracellular effector in hepatocytes for suppressing HBV replication to implicate a possible mechanism of non-cytopathic viral clearance. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | HEPATOCYTE NUCLEAR FACTORS | - |
dc.subject | TRANSGENIC MICE | - |
dc.subject | TNF-ALPHA | - |
dc.subject | VIRAL-HEPATITIS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | IN-VIVO | - |
dc.subject | REPLICATION | - |
dc.subject | INFECTION | - |
dc.subject | INTERFERON | - |
dc.subject | IL-32 | - |
dc.title | Intracellular interleukin-32 gamma mediates antiviral activity of cytokines against hepatitis B virus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Sik | - |
dc.contributor.affiliatedAuthor | Song, Moon Jung | - |
dc.identifier.doi | 10.1038/s41467-018-05782-5 | - |
dc.identifier.scopusid | 2-s2.0-85051694123 | - |
dc.identifier.wosid | 000441768300015 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.9 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | HEPATOCYTE NUCLEAR FACTORS | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | VIRAL-HEPATITIS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | INTERFERON | - |
dc.subject.keywordPlus | IL-32 | - |
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