Central role of autophagic UVRAG in melanogenesis and the suntan response
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Yongfei | - |
dc.contributor.author | Jang, Gyu-beom | - |
dc.contributor.author | Yang, Xuanjun | - |
dc.contributor.author | Wang, Qiaoxiu | - |
dc.contributor.author | He, Shanshan | - |
dc.contributor.author | Li, Shun | - |
dc.contributor.author | Quach, Christine | - |
dc.contributor.author | Zhao, Shihui | - |
dc.contributor.author | Li, Fan | - |
dc.contributor.author | Yuan, Zengqiang | - |
dc.contributor.author | Lee, Hye-Ra | - |
dc.contributor.author | Zhong, Hanbing | - |
dc.contributor.author | Liang, Chengyu | - |
dc.date.accessioned | 2021-09-02T07:44:43Z | - |
dc.date.available | 2021-09-02T07:44:43Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-08-14 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73768 | - |
dc.description.abstract | UV-induced cell pigmentation represents an important mechanism against skin cancers. Sun-exposed skin secretes alpha-MSH, which induces the lineage-specific transcriptional factor MITF and activates melanogenesis in melanocytes. Here, we show that the autophagic tumor suppressor UVRAG plays an integral role in melanogenesis by interaction with the biogenesis of lysosome-related organelles complex 1 (BLOC-1). This interaction is required for BLOC-1 stability and for BLOC-1-mediated cargo sorting and delivery to melanosomes. Absence of UVRAG dispersed BLOC-1 distribution and activity, resulting in impaired melanogenesis in vitro and defective melanocyte development in zebrafish in vivo. Furthermore, our results establish UVRAG as an important effector for melanocytes' response to alpha-MSH signaling as a direct target of MITF and reveal the molecular basis underlying the association between oncogenic BRAF and compromised UV protection in melanoma. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | LYSOSOME-RELATED ORGANELLES | - |
dc.subject | MELANOSOME BIOGENESIS | - |
dc.subject | MALIGNANT-MELANOMA | - |
dc.subject | MASTER REGULATOR | - |
dc.subject | COMPLEX-1 BLOC-1 | - |
dc.subject | RAT HEPATOCYTES | - |
dc.subject | BRAF MUTATIONS | - |
dc.subject | MITF | - |
dc.subject | TRANSPORT | - |
dc.subject | ENDOSOMES | - |
dc.title | Central role of autophagic UVRAG in melanogenesis and the suntan response | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hye-Ra | - |
dc.identifier.doi | 10.1073/pnas.1803303115 | - |
dc.identifier.scopusid | 2-s2.0-85052756849 | - |
dc.identifier.wosid | 000441638200012 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.115, no.33, pp.E7728 - E7737 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 115 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | E7728 | - |
dc.citation.endPage | E7737 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | LYSOSOME-RELATED ORGANELLES | - |
dc.subject.keywordPlus | MELANOSOME BIOGENESIS | - |
dc.subject.keywordPlus | MALIGNANT-MELANOMA | - |
dc.subject.keywordPlus | MASTER REGULATOR | - |
dc.subject.keywordPlus | COMPLEX-1 BLOC-1 | - |
dc.subject.keywordPlus | RAT HEPATOCYTES | - |
dc.subject.keywordPlus | BRAF MUTATIONS | - |
dc.subject.keywordPlus | MITF | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | ENDOSOMES | - |
dc.subject.keywordAuthor | UVRAG | - |
dc.subject.keywordAuthor | MITF | - |
dc.subject.keywordAuthor | BLOC-1 | - |
dc.subject.keywordAuthor | melanosome | - |
dc.subject.keywordAuthor | BRAF | - |
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