Adjuvant concurrent chemoradiation therapy in patients with microscopic residual tumor after curative resection for extrahepatic cholangiocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Lee, J. | - |
dc.contributor.author | Kang, S. H. | - |
dc.contributor.author | Noh, O. K. | - |
dc.contributor.author | Chun, M. | - |
dc.contributor.author | Oh, Y. -T. | - |
dc.contributor.author | Kim, B. -W. | - |
dc.contributor.author | Kim, S. -W. | - |
dc.date.accessioned | 2021-09-02T07:57:02Z | - |
dc.date.available | 2021-09-02T07:57:02Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 1699-048X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73832 | - |
dc.description.abstract | We investigated the role of adjuvant concurrent chemoradiation therapy (CCRT) in patients with a microscopically positive resection margin (R1) after curative resection for extrahepatic cholangiocarcinoma (EHCC). A total of 84 patients treated with curative resection for EHCC were included. Fifty-two patients with negative resection margins did not receive any adjuvant treatments (R0 + S group). The remaining 32 patients with microscopically positive resection margins received either adjuvant CCRT (R1 + CCRT group, n = 19) or adjuvant radiation therapy (RT) alone (R1 + RT group, n = 13). During the median follow-up period of 26 months, the 2-year locoregional recurrence-free survival (LRRFS), disease-free survival (DFS), and overall survival rates (OS) were: 81.8, 62.6, and 61.5% for R0 + S group; 71.8, 57.8, and 57.9% for R1 + CCRT group; and 16.8, 9.6, and 15.4% for R1 + RT group, respectively. Multivariate analysis revealed that the R1 + CCRT group did not show any significant difference in survival rates compared with the R0 + S group. The R1 + RT group had lower LRRFS [hazard ratio (HR) 3.008; p = 0.044], DFS (HR 2.364; p = 0.022), and OS (HR 2.417; p = 0.011) when compared with the R0 + S and R1 + CCRT group. A lack of significant survival difference between R0 + S group and R1 + CCRT group suggests that adjuvant CCRT ameliorates the negative effect of microscopic positive resection margin. In contrast, adjuvant RT alone is appeared to be inadequate for controlling microscopically residual tumor. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER-VERLAG ITALIA SRL | - |
dc.subject | BILE-DUCT CANCER | - |
dc.subject | HILAR CHOLANGIOCARCINOMA | - |
dc.subject | MARGIN STATUS | - |
dc.subject | RECURRENCE | - |
dc.subject | RADIOTHERAPY | - |
dc.subject | SURVIVAL | - |
dc.subject | IMPACT | - |
dc.subject | MANAGEMENT | - |
dc.subject | CARCINOMA | - |
dc.subject | RADIATION | - |
dc.title | Adjuvant concurrent chemoradiation therapy in patients with microscopic residual tumor after curative resection for extrahepatic cholangiocarcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, J. | - |
dc.identifier.doi | 10.1007/s12094-017-1815-y | - |
dc.identifier.scopusid | 2-s2.0-85038369493 | - |
dc.identifier.wosid | 000438705900007 | - |
dc.identifier.bibliographicCitation | CLINICAL & TRANSLATIONAL ONCOLOGY, v.20, no.8, pp.1011 - 1017 | - |
dc.relation.isPartOf | CLINICAL & TRANSLATIONAL ONCOLOGY | - |
dc.citation.title | CLINICAL & TRANSLATIONAL ONCOLOGY | - |
dc.citation.volume | 20 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1011 | - |
dc.citation.endPage | 1017 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | BILE-DUCT CANCER | - |
dc.subject.keywordPlus | HILAR CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | MARGIN STATUS | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordAuthor | Extrahepatic cholangiocarcinoma | - |
dc.subject.keywordAuthor | Concurrent chemoradiation therapy | - |
dc.subject.keywordAuthor | Positive surgical margin | - |
dc.subject.keywordAuthor | Survival | - |
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