Nonimmunogenetic Viral Capsid Carrier with Cancer Targeting Activity
- Authors
- Lee, Bo-Ram; Jo, Eunji; Yoon, Hong Yeol; Yoon, Chul Joo; Lee, Hyo-Jung; Kwon, Koo Chul; Kim, Tae Woo; Lee, Jeewon
- Issue Date
- 8월-2018
- Publisher
- WILEY
- Keywords
- albumin; albumin-binding peptides; immunogenicity; protein nanoparticles; tumor targeting; viral capsids
- Citation
- ADVANCED SCIENCE, v.5, no.8
- Indexed
- SCIE
SCOPUS
- Journal Title
- ADVANCED SCIENCE
- Volume
- 5
- Number
- 8
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/73863
- DOI
- 10.1002/advs.201800494
- ISSN
- 2198-3844
- Abstract
- Although protein nanoparticles (PNPs) (e.g., viral capsids) capable of delivering a broad range of drug agents have shown distinctive advantages over synthetic nanomaterials, PNPs have an intrinsic drawback that hampers their clinical application, that is, potential immunogenicity. Here, a novel method for resolving the immunogenicity problem of PNPs, which is based on the genetic presentation of albumin-binding peptides (ABPs) on the surface of PNP, is reported. ABPs are inserted into the surface of a viral capsid (hepatitis B virus capsid/HBVC) while preserving the native self-assembly function of HBVC. The ABPs effectively gather human serum albumins around HBVC and significantly reduce both inflammatory response and immunoglobulin titer in live mice compared to ABP-free HBVC. Furthermore, ABP-conjugated HBVCs remain within tumors for a longer period than HBVCs conjugated to tumor cell receptor-bindingpeptides, indicating that the ABPs are also capable of enhancing tumor-targeting performance. Although applied to HBVC for proof of concept, this novel approach may provide a general platform for resolving immunogenicity and cancer-targeting problems of PNPs, which enables the development of a variety of PNP-based drug delivery carriers with high safety and efficacy.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Engineering > Department of Chemical and Biological Engineering > 1. Journal Articles
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