Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ma, Siming | - |
dc.contributor.author | Avanesov, Andrei S. | - |
dc.contributor.author | Porter, Emily | - |
dc.contributor.author | Lee, Byung Cheon | - |
dc.contributor.author | Mariotti, Marco | - |
dc.contributor.author | Zemskaya, Nadezhda | - |
dc.contributor.author | Guigo, Roderic | - |
dc.contributor.author | Moskalev, Alexey A. | - |
dc.contributor.author | Gladyshev, Vadim N. | - |
dc.date.accessioned | 2021-09-02T08:35:58Z | - |
dc.date.available | 2021-09-02T08:35:58Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 1474-9718 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74224 | - |
dc.description.abstract | Lifespan varies dramatically among species, but the biological basis is not well understood. Previous studies in model organisms revealed the importance of nutrient sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling in lifespan control. By studying life-history traits and transcriptomes of 14 Drosophila species differing more than sixfold in lifespan, we explored expression divergence and identified genes and processes that correlate with longevity. These longevity signatures suggested that longer-lived flies upregulate fatty acid metabolism, downregulate neuronal system development and activin signaling, and alter dynamics of RNA splicing. Interestingly, these gene expression patterns resembled those of flies under dietary restriction and several other lifespan-extending interventions, although on the individual gene level, there was no significant overlap with genes previously reported to have lifespan-extension effects. We experimentally tested the lifespan regulation potential of several candidate genes and found no consistent effects, suggesting that individual genes generally do not explain the observed longevity patterns. Instead, it appears that lifespan regulation across species is modulated by complex relationships at the system level represented by global gene expression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | EXTENDS LIFE-SPAN | - |
dc.subject | GENE-EXPRESSION PROFILES | - |
dc.subject | EVOLUTIONARY GENETICS | - |
dc.subject | PHYLOGENETIC ANALYSIS | - |
dc.subject | SUPEROXIDE-DISMUTASE | - |
dc.subject | DIETARY RESTRICTION | - |
dc.subject | COMMON SIGNATURES | - |
dc.subject | DIVERGENCE TIMES | - |
dc.subject | TEMPORAL CONTROL | - |
dc.subject | MORTALITY-RATES | - |
dc.title | Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Byung Cheon | - |
dc.identifier.doi | 10.1111/acel.12740 | - |
dc.identifier.scopusid | 2-s2.0-85045762497 | - |
dc.identifier.wosid | 000439767700003 | - |
dc.identifier.bibliographicCitation | AGING CELL, v.17, no.4 | - |
dc.relation.isPartOf | AGING CELL | - |
dc.citation.title | AGING CELL | - |
dc.citation.volume | 17 | - |
dc.citation.number | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.subject.keywordPlus | EXTENDS LIFE-SPAN | - |
dc.subject.keywordPlus | GENE-EXPRESSION PROFILES | - |
dc.subject.keywordPlus | EVOLUTIONARY GENETICS | - |
dc.subject.keywordPlus | PHYLOGENETIC ANALYSIS | - |
dc.subject.keywordPlus | SUPEROXIDE-DISMUTASE | - |
dc.subject.keywordPlus | DIETARY RESTRICTION | - |
dc.subject.keywordPlus | COMMON SIGNATURES | - |
dc.subject.keywordPlus | DIVERGENCE TIMES | - |
dc.subject.keywordPlus | TEMPORAL CONTROL | - |
dc.subject.keywordPlus | MORTALITY-RATES | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | gene expression | - |
dc.subject.keywordAuthor | lifespan | - |
dc.subject.keywordAuthor | Drosophila | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.