Association between anti-Porphyromonas gingivalis antibody, anti-citrullinated protein antibodies, and rheumatoid arthritis A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Bae, S. -C. | - |
dc.contributor.author | Lee, Y. H. | - |
dc.date.accessioned | 2021-09-02T08:37:19Z | - |
dc.date.available | 2021-09-02T08:37:19Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 0340-1855 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74235 | - |
dc.description.abstract | The aim of this study was to determine the relationship between anti-Porphyromonas gingivalis (anti-P. gingivalis) antibody levels and rheumatoid arthritis (RA) and its correlation with anti-citrullinated protein antibodies (ACPA). We performed a meta-analysis of studies comparing (a) anti-P. gingivalis antibody levels in RA patients and healthy controls and (b) the correlation coefficients between the anti-P. gingivalis antibody levels and ACPA in RA patients. The study included 14 articles with 3829 RA patients and 1239 controls. Our meta-analysis showed that anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group (standardized mean difference [SMD] = 0.630, 95% CI = 0.272-0.989, p = 0.001). Subgroup analysis revealed that RA patients had significantly elevated anti-P. gingivalis antibody levels compared with healthy controls, but not compared with the non-RA control group and also not between different sample sizes. Anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group in the age-/sex-matched population, but not in the unmatched population. Anti-P. gingivalis antibody levels were significantly higher in the ACPA-positive group than in the ACPA-negative group (SMD = 0.322, 95% CI = 0.164-0.480, p = 6.4 x 10(-5)). Meta-analysis of the correlation coefficients showed a significant positive correlation between anti-P. gingivalis antibody levels and ACPA (correlation coefficient = 0.147, 95% CI = 0.033-0.258, p = 0.012). Our meta-analysis demonstrated that anti-P. gingivalis antibody levels were significantly higher in patients with RA and they were positively correlated with ACPA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | PUBLICATION BIAS | - |
dc.subject | DISEASE | - |
dc.subject | AUTOANTIBODIES | - |
dc.subject | PERIODONTITIS | - |
dc.subject | AUTOIMMUNITY | - |
dc.subject | RESPONSES | - |
dc.subject | SMOKING | - |
dc.subject | RISK | - |
dc.title | Association between anti-Porphyromonas gingivalis antibody, anti-citrullinated protein antibodies, and rheumatoid arthritis A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.doi | 10.1007/s00393-017-0328-y | - |
dc.identifier.scopusid | 2-s2.0-85019686665 | - |
dc.identifier.wosid | 000441111600011 | - |
dc.identifier.bibliographicCitation | ZEITSCHRIFT FUR RHEUMATOLOGIE, v.77, no.6, pp.522 - 532 | - |
dc.relation.isPartOf | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.citation.title | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.citation.volume | 77 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 522 | - |
dc.citation.endPage | 532 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | PUBLICATION BIAS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | AUTOANTIBODIES | - |
dc.subject.keywordPlus | PERIODONTITIS | - |
dc.subject.keywordPlus | AUTOIMMUNITY | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | SMOKING | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Anti-P. gingivalis antibody | - |
dc.subject.keywordAuthor | Anti-citrullinated protein antibodies | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
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