Decreased expression of bone morphogenetic protein-2 is correlated with biochemical recurrence in prostate cancer: Immunohistochemical analysis
DC Field | Value | Language |
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dc.contributor.author | Tae, Bum Sik | - |
dc.contributor.author | Cho, Seok | - |
dc.contributor.author | Kim, Hyun Cheol | - |
dc.contributor.author | Kim, Cheol Hwan | - |
dc.contributor.author | Kang, Seok Ho | - |
dc.contributor.author | Lee, Jeong Gu | - |
dc.contributor.author | Kim, Je Jong | - |
dc.contributor.author | Park, Hong Seok | - |
dc.contributor.author | Cheon, Jun | - |
dc.contributor.author | Oh, Mi Mi | - |
dc.contributor.author | Kang, Sung Gu | - |
dc.date.accessioned | 2021-09-02T08:58:03Z | - |
dc.date.available | 2021-09-02T08:58:03Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-07-16 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74336 | - |
dc.description.abstract | We evaluated the prognostic value of BMP-2 expression in prostate cancer tissue via immunohistochemistry in prostate cancer patients. From July 2007 to August 2010, radical prostatectomy specimens from 90 patients with clinically localized prostate cancer (mean age, 62.7 years, mean follow-up 90.4 months) were assessed for BMP-2 expression using immunohistochemistry. We used stepwise multivariate Cox regression models stratified by study to assess the independent effects of the predictive factors and estimated hazard ratios (HRs). There were significant differences in the baseline characteristics of Gleason score (GS) and biochemical recurrence (BCR) between the groups with decreased and normal BMP-2 expression. Univariate analysis revealed GS, T stage (>= T3), and decreased BMP-2 expression as significant predictive determinants of BCR. In addition, GS (7: HR 2.836, p = 0.022; >= 8: HR 3.506, p = 0.048) and decreased BMP-2 expression (HR 2.007, p = 0.047) were significantly correlated with BCR in multivariate analysis. Overall five-year BCR-free survival rates in the group with decreased BMP-2 expression were worse than those in the group with normal expression. Therefore, decreased BMP-2 expression in prostate cancer tissue was correlated with the prognostic factors for BCR-free survival in patients with prostate cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | RADICAL PROSTATECTOMY | - |
dc.subject | METASTATIC PROSTATE | - |
dc.subject | BREAST-CANCER | - |
dc.subject | CELLS | - |
dc.subject | BMP-2 | - |
dc.subject | APOPTOSIS | - |
dc.subject | SURVIVAL | - |
dc.subject | MEN | - |
dc.title | Decreased expression of bone morphogenetic protein-2 is correlated with biochemical recurrence in prostate cancer: Immunohistochemical analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Tae, Bum Sik | - |
dc.contributor.affiliatedAuthor | Kim, Cheol Hwan | - |
dc.contributor.affiliatedAuthor | Kang, Seok Ho | - |
dc.contributor.affiliatedAuthor | Lee, Jeong Gu | - |
dc.contributor.affiliatedAuthor | Kim, Je Jong | - |
dc.contributor.affiliatedAuthor | Park, Hong Seok | - |
dc.contributor.affiliatedAuthor | Cheon, Jun | - |
dc.contributor.affiliatedAuthor | Oh, Mi Mi | - |
dc.contributor.affiliatedAuthor | Kang, Sung Gu | - |
dc.identifier.doi | 10.1038/s41598-018-28566-9 | - |
dc.identifier.scopusid | 2-s2.0-85050393535 | - |
dc.identifier.wosid | 000438679100053 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.8 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | RADICAL PROSTATECTOMY | - |
dc.subject.keywordPlus | METASTATIC PROSTATE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | MEN | - |
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