Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Lee, Jae Yong | - |
dc.contributor.author | Shim, Kyu-Sik | - |
dc.contributor.author | Lee, Sunghee | - |
dc.contributor.author | Min, Kyoengwoo | - |
dc.contributor.author | Bae, Ji-Hoon | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Song, Hae-Ryong | - |
dc.date.accessioned | 2021-09-02T08:58:37Z | - |
dc.date.available | 2021-09-02T08:58:37Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-07-15 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74340 | - |
dc.description.abstract | The aim of this study was to investigate the effects of a sulfasalazine-containing hyaluronic acid (SASP/HA) systems on in vitro anti-inflammation and the alleviation of cartilage degradation in both lipopolysaccharide (LPS)-stimulated synoviocytes and a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA). The SASP/HA resulted in long-term release of SASP from the SASP/HA for up to 60 days in a sustained manner. In vitro studies performed using real-time polymerase chain reaction (PCR) assay revealed that the SASP/HA was able to effectively and dose-dependently inhibit the mRNA expression levels of pro-inflammatory cytokines such as matrix metalloproteinases-3 (MMP-3), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in LPS-stimulated synoviocytes. In vivo studies showed that intra articular injection of SASP/HA greatly reduced the MR-stimulated mRNA expression of MMP-3, COX-2, IL-6, and TNF-alpha in blood. Furthermore, these significant anti-inflammatory effects of SASP/HA contributed markedly to the alleviation of progression of MIA-induced OA and cartilage degradation, as demonstrated by X-ray, micro-computed tomography (micro-CT), gross findings, and histological evaluations. Therefore, our findings indicated that the long-term and sustained delivery of SASP using HA can play a therapeutic role in alleviating inflammation as well as protecting against cartilage damage in OA. (C) 2018 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | FACTOR-KAPPA-B | - |
dc.subject | MATRIX METALLOPROTEINASES | - |
dc.subject | KNEE OSTEOARTHRITIS | - |
dc.subject | MECHANISMS | - |
dc.subject | INHIBITOR | - |
dc.subject | CHONDROCYTES | - |
dc.subject | COLLAGENASE | - |
dc.subject | INDUCTION | - |
dc.subject | CYTOKINES | - |
dc.subject | ARTHRITIS | - |
dc.title | Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.contributor.affiliatedAuthor | Bae, Ji-Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Hak-Jun | - |
dc.contributor.affiliatedAuthor | Song, Hae-Ryong | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2018.03.059 | - |
dc.identifier.scopusid | 2-s2.0-85044516667 | - |
dc.identifier.wosid | 000435056900039 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.114, pp.341 - 348 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - |
dc.citation.volume | 114 | - |
dc.citation.startPage | 341 | - |
dc.citation.endPage | 348 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | KNEE OSTEOARTHRITIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | CHONDROCYTES | - |
dc.subject.keywordPlus | COLLAGENASE | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordAuthor | Sulfasalazine | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Osteoarthritis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.