Senescent tumor cells building three-dimensional tumor clusters
- Authors
- Lee, Hyun-Gyu; Kim, June Hoan; Sun, Woong; Chi, Sung-Gil; Choi, Wonshik; Lee, Kyoung J.
- Issue Date
- 12-7월-2018
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v.8
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 8
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/74351
- DOI
- 10.1038/s41598-018-28963-0
- ISSN
- 2045-2322
- Abstract
- Cellular senescence, a permanent cell-cycle arrest, is a common yet intriguing phenomenon, in which its beneficial significance for biological organisms has only begun to be explored. Among others, senescent cells are able to transform tissue structures around them. Tumor cells, whose hallmark is their ability to proliferate indefinitely, are not free from the phenomenon. Here, we report a remarkable observation where senescent cells in a dense mono-layer of breast cancer colony act as aggregating centers for non-senescent cells in their vicinity. Consequently, the senescent cells actively form localized 3D cell-clusters in a confluent 2D tumor layer. The biophysical mechanism underpinning the surprising phenomenon primarily involves mitotic cell-rounding, dynamic and differential cell attachments, and cellular chemotaxis. By incorporating these few biophysical factors, we were able to recapitulate the experimental observation via a cellular Potts Model.
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- Appears in
Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- Graduate School > Department of Life Sciences > 1. Journal Articles
- College of Science > Department of Physics > 1. Journal Articles
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