Age-dependent prognostic value of body mass index for non-metastatic clear cell renal cell carcinoma: A large multicenter retrospective analysis
DC Field | Value | Language |
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dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Hwang, Eu C. | - |
dc.contributor.author | Kang, Seok H. | - |
dc.contributor.author | Hong, Sung-Hoo | - |
dc.contributor.author | Chung, Jinsoo | - |
dc.contributor.author | Kwon, Tae G. | - |
dc.contributor.author | Kim, Hyeon H. | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Kim, Yong-June | - |
dc.contributor.author | Lee, Won K. | - |
dc.date.accessioned | 2021-09-02T09:04:02Z | - |
dc.date.available | 2021-09-02T09:04:02Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-07-01 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74381 | - |
dc.description.abstract | Background and Objectives: The prognostic value of obesity is unestablished for renal cell carcinoma. We assessed the age-dependent prognostic value of body mass index (BMI) in a large multicenter cohort of patients with non-metastatic clear cell renal cell carcinoma (nm-cRCC). Methods: This study evaluated 2092 patients with nm-cRCC who underwent surgery with curative intent at five Korean institutions between 2001 and 2014. Results: There was no significant difference in BMI between the young (<45 years) and older patients (>= 45 years) (P=0.398). Among older patients, high BMI (>= 25 kg/m(2)) was associated with better 5-year rates of recurrence-free survival (RFS) and cancer-specific survival (CSS) (P=0.003 and 0.004, respectively), and multivariate analysis confirmed that high BMI was independently associated with better RFS and CSS (RFS hazard ratio [HR]: 0.617, P=0.005; CSS HR: 0.588, P=0.024). However, among young patients, there were no significant BMI-related differences in the 5-year RFS and CSS rates (P=0.457 and 0.420, respectively), and high BMI was not independently associated with RFS or CSS (P=0.822 and 0.749, respectively). Conclusions: Among patients with nm-cRCC, high BMI was associated with a favorable prognosis among older patients but not among young patients. Therefore, the relationship between obesity and nm-cRCC prognosis might vary according to age. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | COHORT ANALYSIS | - |
dc.subject | KIDNEY CANCER | - |
dc.subject | OBESITY | - |
dc.subject | SURVIVAL | - |
dc.subject | IMPACT | - |
dc.subject | METAANALYSIS | - |
dc.subject | OVERWEIGHT | - |
dc.subject | MORTALITY | - |
dc.subject | PARADOX | - |
dc.subject | UPDATE | - |
dc.title | Age-dependent prognostic value of body mass index for non-metastatic clear cell renal cell carcinoma: A large multicenter retrospective analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Seok H. | - |
dc.identifier.doi | 10.1002/jso.25104 | - |
dc.identifier.scopusid | 2-s2.0-85053238989 | - |
dc.identifier.wosid | 000444420200026 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, v.118, no.1, pp.199 - 205 | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.citation.title | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.citation.volume | 118 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 205 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | COHORT ANALYSIS | - |
dc.subject.keywordPlus | KIDNEY CANCER | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | OVERWEIGHT | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | PARADOX | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordAuthor | age | - |
dc.subject.keywordAuthor | body mass index | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | renal cell carcinoma | - |
dc.subject.keywordAuthor | survival | - |
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