PRMT1 negatively regulates activation-induced cell death in macrophages by arginine methylation of GAPDH
DC Field | Value | Language |
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dc.contributor.author | Cho, Jun-Ho | - |
dc.contributor.author | Lee, Rana | - |
dc.contributor.author | Kim, Eunju | - |
dc.contributor.author | Choi, Yea Eun | - |
dc.contributor.author | Choi, Eui-Ju | - |
dc.date.accessioned | 2021-09-02T09:04:35Z | - |
dc.date.available | 2021-09-02T09:04:35Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-07-01 | - |
dc.identifier.issn | 0014-4827 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74386 | - |
dc.description.abstract | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is implicated in cell death in addition to a role as a glycolytic enzyme. In particular, when cells are exposed to cellular stressors involving nitric oxide (NO) production, GAPDH can undergo NO -induced S-nitrosylation and S-nitrosylated GAPDH has been shown to elicit apoptosis. However, the mechanism underlying the regulation of the pro-apoptotic function of GAPDH remains unclear. Here, we found that protein arginine methyltransferase 1 (PRMT1) mediated arginine methylation of GAPDH in primary bone marrow-derived macrophages in a NO-dependent manner. Moreover, PRMT1 inhibited S-nitrosylation of GAPDH as well as its binding to STAHl, thereby reducing the nuclear translocation of GAPDH in lipopolysaccharide (LPS)/interferon (IFN)-gamma-activated macrophages. Furthermore, depletion of PRMT1 expression by RNA interference potentiated LPS/IFN-gamma-induced apoptosis in macrophages. Taken together, our results suggest that PRMT1 has a previously unrecognized function to inhibit activation-induced cell death of macrophages through arginine methylation of GAPDH. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER INC | - |
dc.subject | PROTEIN S-NITROSYLATION | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | NUCLEAR TRANSLOCATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | PATHWAYS | - |
dc.subject | STRESS | - |
dc.subject | BINDS | - |
dc.subject | GAMMA | - |
dc.subject | ASK1 | - |
dc.title | PRMT1 negatively regulates activation-induced cell death in macrophages by arginine methylation of GAPDH | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Eui-Ju | - |
dc.identifier.doi | 10.1016/j.yexcr.2018.04.012 | - |
dc.identifier.scopusid | 2-s2.0-85045877391 | - |
dc.identifier.wosid | 000433267500006 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL CELL RESEARCH, v.368, no.1, pp.50 - 58 | - |
dc.relation.isPartOf | EXPERIMENTAL CELL RESEARCH | - |
dc.citation.title | EXPERIMENTAL CELL RESEARCH | - |
dc.citation.volume | 368 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 50 | - |
dc.citation.endPage | 58 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | PROTEIN S-NITROSYLATION | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | NUCLEAR TRANSLOCATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | BINDS | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | ASK1 | - |
dc.subject.keywordAuthor | Arginine methylation/GAPDH/macrophage/nitric oxide/PRMT1 | - |
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