Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation
DC Field | Value | Language |
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dc.contributor.author | Zhang, Yuan | - |
dc.contributor.author | Kim, Tae-Jin | - |
dc.contributor.author | Wroblewska, Joanna A. | - |
dc.contributor.author | Tesic, Vera | - |
dc.contributor.author | Upadhyay, Vaibhav | - |
dc.contributor.author | Weichselbaum, Ralph R. | - |
dc.contributor.author | Tumanov, Alexei V. | - |
dc.contributor.author | Tang, Hong | - |
dc.contributor.author | Guo, Xiaohuan | - |
dc.contributor.author | Tang, Haidong | - |
dc.contributor.author | Fu, Yang-Xin | - |
dc.date.accessioned | 2021-09-02T09:09:18Z | - |
dc.date.available | 2021-09-02T09:09:18Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.issn | 1672-7681 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74422 | - |
dc.description.abstract | Splenomegaly is a well-known phenomenon typically associated with inflammation. However, the underlying cause of this phenotype has not been well characterized. Furthermore, the splenomegaly phenotype seen in lymphotoxin (LT) signaling-deficient mice is characterized by increased numbers of splenocytes and splenic neutrophils. Splenomegaly, as well as the related phenotype of increased lymphocyte counts in non-lymphoid tissues, is thought to result from the absence of secondary lymphoid tissues in LT-deficient mice. We now present evidence that mice deficient in LT alpha(1)beta(2) or LT beta R develop splenomegaly and increased numbers of lymphocytes in non-lymphoid tissues in a microbiota-dependent manner. Antibiotic administration to LT alpha(1)beta(2)- or LT beta R-deficient mice reduces splenomegaly. Furthermore, re-derived germ-free Ltbr(-/- ) mice do not exhibit splenomegaly or increased inflammation in non-lymphoid tissues compared to specific pathogen-free Ltbr(-/- )mice. By using various LID- and LTM-conditional knockout mice, we demonstrate that retinoic acid-related orphan receptor gamma T-positive type 3 innate lymphoid cells provide the required active LT signaling to prevent the development of splenomegaly. Thus, this study demonstrates the importance of LT-mediated immune responses for the prevention of splenomegaly and systemic inflammation induced by microbiota. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CHIN SOCIETY IMMUNOLOGY | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | ROR-GAMMA-T | - |
dc.subject | MHC CLASS-II | - |
dc.subject | BETA-RECEPTOR | - |
dc.subject | INTESTINAL INFLAMMATION | - |
dc.subject | ABNORMAL-DEVELOPMENT | - |
dc.subject | FUNCTIONAL BIOLOGY | - |
dc.subject | B-CELLS | - |
dc.subject | MICE | - |
dc.subject | DEFICIENT | - |
dc.title | Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Jin | - |
dc.identifier.doi | 10.1038/cmi.2017.25 | - |
dc.identifier.scopusid | 2-s2.0-85052791579 | - |
dc.identifier.wosid | 000448426600009 | - |
dc.identifier.bibliographicCitation | CELLULAR & MOLECULAR IMMUNOLOGY, v.15, no.7, pp.697 - 709 | - |
dc.relation.isPartOf | CELLULAR & MOLECULAR IMMUNOLOGY | - |
dc.citation.title | CELLULAR & MOLECULAR IMMUNOLOGY | - |
dc.citation.volume | 15 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 697 | - |
dc.citation.endPage | 709 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | ROR-GAMMA-T | - |
dc.subject.keywordPlus | MHC CLASS-II | - |
dc.subject.keywordPlus | BETA-RECEPTOR | - |
dc.subject.keywordPlus | INTESTINAL INFLAMMATION | - |
dc.subject.keywordPlus | ABNORMAL-DEVELOPMENT | - |
dc.subject.keywordPlus | FUNCTIONAL BIOLOGY | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | DEFICIENT | - |
dc.subject.keywordAuthor | germ-free | - |
dc.subject.keywordAuthor | lymphotoxin | - |
dc.subject.keywordAuthor | microbiota | - |
dc.subject.keywordAuthor | splenomegaly | - |
dc.subject.keywordAuthor | type 3 innate lymphoid cells | - |
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